通讯作者: 邓鑫, dx8848@126.com

DOI：10.12201/bmr.202610.00009

• 摘要：络病理论强调久病入络、痰瘀阻络及络阻成积的学术思想，与肝纤维化由功能失调逐渐进展至微循环障碍和组织结构重塑的病理演变特点具有内在契合性。本文以络病理论为切入点，结合现代肝纤维化病理机制，探讨痰、瘀在疾病进展中的相互影响及其阻滞、损伤肝络的过程，提出“痰瘀互结—络阻成积”是肝纤维化演变过程中重要病机主线，并据此从调肝健脾、痰瘀同治、逐瘀通络及软坚扶正等方面构建分期论治思路。旨在从络病视角重新认识肝纤维化的动态病机特点，为中医辨证分期及临床干预提供理论参考。

  关键词： 肝纤维化; 络病理论; 痰瘀互结; 络阻成积; 分期论治

   

  Abstract: Collateral disease theory emphasizes the pathological evolution of chronic disease involving the collaterals, obstruction of the collaterals by phlegm and blood stasis, and the eventual formation of accumulation due to persistent collateral obstruction. These concepts are consistent, at the level of pathological evolution, with the progression of liver fibrosis from functional dysregulation to microcirculatory disturbance and structural remodeling. Based on collateral disease theory and current understanding of the pathological mechanisms of liver fibrosis, this article explores the dynamic interactions among phlegm, blood stasis, and collateral dysfunction during disease progression. It proposes that “binding of phlegm and blood stasis followed by collateral obstruction and accumulation formation” represents a key pathological process in the evolution of liver fibrosis. Accordingly, a stage-oriented therapeutic approach is proposed, including eliminating pathogenic factors while regulating the liver and strengthening the spleen, simultaneously resolving phlegm and activating blood circulation, removing blood stasis and unblocking the collaterals, and softening accumulation while supporting healthy qi and nourishing the collaterals. This article provides a collateral disease–based perspective for understanding the dynamic pathogenesis of liver fibrosis and may offer a theoretical basis for syndrome differentiation, stage-oriented treatment, and clinical intervention in traditional Chinese medicine.

  Key words: : Liver fibrosis; Collateral disease theory; Phlegm and blood stasis binding; Collateral obstruction and accumulation formation; Stage-oriented treatment

  提交时间：2026-10-08

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  2	2026-09-22	10.12201/bmr.202610.00009V2	下载
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