通讯作者: 谢军, 2663708@qq.com

DOI：10.12201/bmr.202606.00071

Treatment of Metabolic-Related Fatty Liver Fibrosis Based on the Theory of “Stagnation Due to Qi Deficiency”

• 摘要：谢军教授认为代谢相关脂肪性肝纤维化可归属于中医学“积聚”范围，其病机始于先天肾精暗耗、脾胃气虚、土不荣木，继则津聚为痰、血停为瘀，痰瘀胶滞肝络，终致肝脾肾同损、精气血俱亏，与“虚气留滞”理论相合。治疗上提出了“补虚行滞固本”的原则，针对脾肾亏虚，土不荣木者以健脾益肾、培土荣木为法，方用自拟消积方加减；针对痰瘀胶着、瘀阻肝络者，以化痰祛瘀、利湿通络为法，方选温胆汤合膈下逐瘀汤加减；针对三脏俱损，精气血亏者，以填精固肾、健脾养肝为法，方取一贯煎合滋水清肝饮化裁。

  关键词： 虚气留滞；代谢相关脂肪性肝纤维化；理论探讨；病机演变; ; ; 

   

  Abstract: Professor Xie Jun believes that metabolic-related fatty liver fibrosis falls within the scope of “ji ju” (accumulation and stagnation) in Traditional Chinese Medicine. Its pathogenesis begins with the gradual depletion of congenital kidney essence, deficiency of spleen and stomach qi, and the failure of Earth to nourish Wood. This is followed by the accumulation of body fluids into phlegm and the stasis of blood into stasis, with phlegm and stasis obstructing the liver meridians. Ultimately, this leads to concurrent damage to the liver, spleen, and kidneys, as well as a deficiency of essence, qi, and blood, which aligns with the theory of “stagnation due to qi deficiency.” The treatment principle proposed is “tonifying deficiency, resolving stagnation, and consolidating the root.” For cases of spleen-kidney deficiency where “Earth fails to nourish Wood,” the approach is to strengthen the spleen, tonify the kidneys, nourish the Earth, and nourish Wood, using a modified version of the self-formulated Xiao Ji Decoction. For cases where phlegm and stasis are entangled and stasis obstructs the liver meridians, the approach is to resolve phlegm, remove stasis, drain dampness, and unblock the meridians, using a modified combination of Wen Dan Decoction and Ge Xia Zhu Yu Decoction. For cases involving damage to all three zang organs and deficiency of essence, qi, and blood, the approach is to replenish essence, consolidate the kidneys, strengthen the spleen, and nourish the liver, using a modified formula combining Yiguan Decoction and Zishui Qinggan Decoction.

  Key words: Qi stagnation due to deficiency; metabolic-related fatty liver fibrosis; theoretical discussion; pathogenesis progression

  提交时间：2026-06-23

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• 序号	提交日期	编号	操作
  1	2026-04-20	10.12201/bmr.202606.00071V1	下载

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