通讯作者: 费丹婷, 1207406645@qq.com

DOI：10.12201/bmr.202609.00014

Clinical value of systemic immune-inflammation index combined with IL-4 and IL-8 in predicting acute lung injury after traumatic brain injury

• 摘要：目的 探讨系统性免疫炎症指数（systemic immune-inflammation index，SII）联合白细胞介素-4（interleukin-4，IL-4）、白细胞介素-8（interleukin-8，IL-8）预测颅脑创伤患者继发急性肺损伤的临床价值。方法 回顾性选取2025年4月至2026年4月收治的颅脑创伤患者498例，根据伤后7 d内是否继发急性肺损伤分为急性肺损伤组（n=126）和对照组（n=372）。收集患者临床资料，检测血清IL-4、IL-8水平并计算SII，分析各指标与急性肺损伤的关系。结果 急性肺损伤组中线移位及早期机械通气占比高于对照组，氧合指数低于对照组（P＜0.05）；其SII、IL-4、IL-8水平均高于对照组（P＜0.05）。校正中线移位、早期机械通气及急诊手术后，SII、IL-4、IL-8仍与颅脑创伤患者继发急性肺损伤相关（P＜0.05）。受试者工作特征曲线分析显示，SII、IL-4、IL-8预测急性肺损伤的曲线下面积分别为0.780、0.796、0.790，三者联合预测的曲线下面积为0.907。结论 SII、IL-4、IL-8联合检测对颅脑创伤继发急性肺损伤具有较高的预测价值，可为临床早期风险识别提供参考。

  关键词： 颅脑创伤；急性肺损伤；系统性免疫炎症指数；白细胞介素-4；白细胞介素-8；预测价值; ; ; ; ; 

   

  Abstract: Objective To evaluate the value of the systemic immune-inflammation index (SII) combined with interleukin-4 (IL-4) and interleukin-8 (IL-8) for predicting acute lung injury (ALI) after traumatic brain injury (TBI). Methods A total of 498 patients with TBI admitted between April 2025 and April 2026 were retrospectively enrolled and classified into an ALI group (n=126) and a control group (n=372) according to whether ALI developed within 7 days after injury. Clinical data were collected, serum IL-4 and IL-8 levels were measured, and SII was calculated. Associations between these indicators and ALI were analyzed. Results The proportions of patients with midline shift and early mechanical ventilation were higher, whereas the oxygenation index was lower, in the ALI group than in the control group (P<0.05). SII, IL-4, and IL-8 levels were higher in the ALI group (P<0.05). After adjustment for midline shift and early mechanical ventilation,and emergency surgery, SII, IL-4, and IL-8 remained associated with ALI after TBI (P<0.05). Receiver operating characteristic curve analysis showed that the areas under the curve for SII, IL-4, and IL-8 were 0.780, 0.796, and 0.790, respectively, and that of the combined model was 0.907. Conclusion Combined assessment of SII, IL-4, and IL-8 has good predictive value for ALI after TBI and may facilitate early clinical risk identification.

  Key words: traumatic brain injury; acute lung injury; systemic immune-inflammation index; interleukin-4; interleukin-8; predictive value

  提交时间：2026-09-09

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• 序号	提交日期	编号	操作
  1	2026-07-12	10.12201/bmr.202609.00014V1	下载

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