通讯作者: 林琳, 1276302825@qq.com

DOI：10.12201/bmr.202606.00080

Research Progress on Mechanism of Nrf2-Mediated Mitophagy in Heart Failure and Intervention with Traditional Chinese Medicine

• 摘要：心力衰竭(heart failure, HF)是各种心血管疾病的终末阶段，其发病机制涉及氧化应激、线粒体功能障碍等多个环节。核因子E2相关因子2 (nuclear factor erythroid 2-related factor 2,Nrf2)是机体氧化应激的核心调控因子，线粒体自噬(Mitochondrial autophagy,MA)则是维持心肌细胞线粒体质量与功能稳定的关键机制。近年研究发现，Nrf2介导的MA通路对延缓HF意义重大。本文阐述二者的结构功能，探讨Nrf2介导MA参与HF病理进程的分子通路，梳理中医药靶向该通路干预HF的研究，为HF的病理机制阐释与临床防治新思路提供理论支撑。

  关键词： 心力衰竭; Nrf2; 线粒体自噬

   

  Abstract: Heart failure (HF) represents the end-stage of various cardiovascular diseases, whose pathogenesis involves multiple pathological processes including oxidative stress and mitochondrial dysfunction. Nuclear factor erythroid 2-related factor 2 (Nrf2) acts as a core regulator of oxidative stress in the organism, while mitochondrial autophagy (MA) serves as a key mechanism maintaining the stability of mitochondrial quality and function in cardiomyocytes.Accumulating evidence in recent years has demonstrated that the Nrf2-mediated MA pathway is of great significance for delaying HF progression. This paper elaborates on the structures and biological functions of Nrf2 and MA, explores the molecular pathways underlying the involvement of Nrf2-mediated MA in the pathological progression of HF, and summarizes research advances in traditional Chinese medicine (TCM) interventions for HF targeting this pathway, so as to provide theoretical support for elucidating HF pathological mechanisms and developing novel strategies for its clinical prevention and treatment.

  Key words: Heart Failure; Nuclear Factor Erythroid 2-Related Factor 2; Mitochondrial Autophagy

  提交时间：2026-06-29

  版权声明：作者本人独立拥有该论文的版权，预印本系统仅拥有论文的永久保存权利。任何人未经允许不得重复使用。
• html

• 图表

• 蔡欣欣, 吴夏阳. SGLT2i治疗心力衰竭的作用机制及研究进展. 2025. doi: 10.12201/bmr.202507.00052

  郑鑫, 常阳, 吴道雄, 李倩倩, 冯茜, 王娓娓△. Nrf2在氧化应激所致动脉粥样硬化中的研究进展. 2025. doi: 10.12201/bmr.202503.00016

  丁瑢, 李劲榆△, 潘佳茵, 吴梦瑶, 王娓娓, 郑鑫. 射血分数保留型心力衰竭中炎症的作用机制和研究进展. 2026. doi: 10.12201/bmr.202603.00045

  苏巧玲, 翁锦龙. 基于“益气活血法”探讨黄芪丹参饮干预慢性心力衰竭的潜在作用机制. 2026. doi: 10.12201/bmr.202601.00043

  周航宇, 李杰. 射血分数保留的心力衰竭合并慢性肾脏疾病的研究进展. 2025. doi: 10.12201/bmr.202504.00077

  李明峻, 翟宁. 人工智能在心力衰竭精准分型中的研究进展与展望. 2025. doi: 10.12201/bmr.202512.00030

  马家慧, 王忠. 心力衰竭患者血浆C1q/肿瘤坏死因子相关蛋白6、系统性炎症反应指数水平及临床意义. 2025. doi: 10.12201/bmr.202501.00060

  杨 欢, 刘 悦. 基于“脾为枢机”理论探讨线粒体自噬介导巨噬细胞焦亡在动脉粥样硬化中的作用. 2025. doi: 10.12201/bmr.202508.00029

  郑杰媚, 邱小芩, 韦吉思, 丘欣雨, 刘娜, 陈思帆. 慢性心力衰竭患者症状群的范围综述. 2025. doi: 10.12201/bmr.202501.00046

  费丽萍, 唐坎凯, 刘凤琪, 陈志冬. α7烟碱型乙酰胆碱受体激动剂对脓毒症小鼠肠损伤及线粒体自噬的影响. 2024. doi: 10.12201/bmr.202410.00066

• 序号	提交日期	编号	操作
  1	2026-05-14	10.12201/bmr.202606.00080V1	下载

• 公开评论  匿名评论  仅发给作者 提交评论