通讯作者: 翁锦龙, 2565260728@qq.com

DOI：10.12201/bmr.202601.00043

Exploring the Potential Mechanism of Astragalus and Salvia Decoction in Intervention of Chronic Heart Failure Based on the Method of Reinforcing Qi and Activating Blood

• 摘要：慢性心力衰竭(chronic heart failure，CHF)是是心血管疾病的终末阶段，气虚血瘀是其核心病机。黄芪丹参饮作为临床经验方，对于气虚血瘀型慢性心力衰竭具有较好疗效，但尚缺乏系统的临床研究。本文围绕“益气活血”法，结合黄芪、丹参等单味药现代药理研究，探讨该方可能通过抑制心肌纤维化、改善能量代谢、抗炎与免疫调节、抗氧化应激、调控神经内分泌及改善胃肠功能等多途径发挥治疗作用，为临床应用与后续深入研究提供理论依据。

  关键词： 慢性心力衰竭；气虚血瘀证；黄芪丹参饮；作用机制；益气活血法; ; ; 

   

  Abstract: Chronic heart failure (CHF) represents the end stage of cardiovascular diseases, with qi deficiency and blood stasis serving as its core pathological mechanism. As a clinically empirical formula, Astragalus and Salvia Decoction has shown favorable therapeutic effects in treating CHF characterized by qi deficiency and blood stasis, though systematic clinical studies are still lacking. Centering on the method of reinforcing qi and activating blood, and incorporating modern pharmacological research on single herbs such as Astragalus and Salvia, this paper explores how the formula may exert its therapeutic effects through multiple pathways. These include inhibiting myocardial fibrosis, improving energy metabolism, exerting anti-inflammatory and immunomodulatory actions, alleviating oxidative stress, regulating neuroendocrine function, and enhancing gastrointestinal function. The findings provide a theoretical basis for clinical application and further in-depth research.

  Key words: Chronic heart failure; Qi Deficiency and Blood Stasis Pattern; Astragalus and Salvia Drink; Mechanism of action；Method of Reinforcing Qi and Activating Blood

  提交时间：2026-01-14

  版权声明：作者本人独立拥有该论文的版权，预印本系统仅拥有论文的永久保存权利。任何人未经允许不得重复使用。
• html

• 图表

• 吴晗, 廖才刚, 杨冯静. 温潜法分期治疗慢性心力衰竭探析. 2025. doi: 10.12201/bmr.202510.00061

  周航宇, 李杰. 射血分数保留的心力衰竭合并慢性肾脏疾病的研究进展. 2025. doi: 10.12201/bmr.202504.00077

  蔡欣欣, 吴夏阳. SGLT2i治疗心力衰竭的作用机制及研究进展. 2025. doi: 10.12201/bmr.202507.00052

  薛琴丹. 健康素养在慢性心力衰竭患者症状负担与疾病不确定感间的调节效应分析. 2024. doi: 10.12201/bmr.202407.00062

  郑杰媚, 邱小芩, 韦吉思, 丘欣雨, 刘娜, 陈思帆. 慢性心力衰竭患者症状群的范围综述. 2025. doi: 10.12201/bmr.202501.00046

  蔡杰, 韩陈媛. 某三级医院慢性射血分数降低心力衰竭住院患者指南导向药物应用分析与评价. 2025. doi: 10.12201/bmr.202507.00076

  祝可昕, 张婷素. 基于时空演化理论探讨血痹发生机制与黄芪桂枝五物汤的应用. 2026. doi: 10.12201/bmr.202601.00049

  邱美洁, 周 杰, 肖 玮. 从气血津液理论探讨COPD合并2型糖尿病氧化应激与代谢失衡的关联机制. 2025. doi: 10.12201/bmr.202506.00039

  吴建奇, 黄鸿鹏, 林燕婷, 李寿杰, 陈晓聪. 从逐瘀化饮法辨治恶性腹水经验. 2025. doi: 10.12201/bmr.202503.00011

  王敏旭, 帕尔哈提·吐尔逊. 炎症与铁缺乏在心力衰竭患者预后中的预测作用. 2025. doi: 10.12201/bmr.202507.00038

• 序号	提交日期	编号	操作
  1	2025-12-08	10.12201/bmr.202601.00043V1	下载

• 公开评论  匿名评论  仅发给作者 提交评论