通讯作者: 李伟, Lw890719@163.com

DOI：10.12201/bmr.202605.00103

A Case-Control Study on the Impact ofHelicobacter pyloriInfection on Iron Stores and Iron Deficiency Anemia in Women of Childbearing Age

• 摘要：目的 研究幽门螺旋杆菌（Hp）感染对育龄女性铁储备及缺铁性贫血影响。方法 选取2023年10月-2025年10月于金华市妇幼保健院确诊并收治的80例患缺铁性贫血的育龄女性作为病例组，同期80例健康育龄女性作为健康组。检测Hp感染状态及血红蛋白、血清铁蛋白等铁代谢与血液学指标，统计胃肠道症状等临床指标。结果 与健康组相比，病例组Hp阳性发生率显著升高，血红蛋白、血清铁蛋白、血清铁显著降低，平均红细胞体积显著缩小（P<0.05）；与Hp阴性组相比，Hp阳性组血红蛋白、血清铁蛋白、血清铁显著降低，平均红细胞体积显著缩小（P<0.05），胃肠道症状、消化道出血、营养状况不佳、非甾体抗炎药使用的发生率显著提高（P<0.05）；Hp阳性病例组与Hp阴性病例组血红蛋白、血清铁蛋白、血清铁、平均红细胞体积无显著差异（P>0.05）。结论 Hp感染与育龄女性铁储备降低及缺铁性贫血发生密切相关，Hp阳性的育龄女性更易出现铁代谢异常及胃肠道相关临床指标异常。

  关键词： 幽门螺旋杆菌感染；育龄女性；铁储备；缺铁性贫血; ; ; 

   

  Abstract: Objective?To investigate the effects of?Helicobacter pylori?(Hp) infection on iron stores and iron deficiency anemia (IDA) in women of childbearing age.?Methods?A total of 80 women of childbearing age diagnosed with IDA at Jinhua Maternal and Child Health Hospital from October 2023 to October 2025 were selected as the case group, and 80 healthy women of childbearing age during the same period were selected as the control group. Hp infection status, hemoglobin, serum ferritin, and other iron metabolism and hematological parameters were measured, and clinical indicators such as gastrointestinal symptoms were recorded.?Results ?Compared with the control group, the case group showed a significantly higher incidence of Hp positivity, significantly lower levels of hemoglobin, serum ferritin, and serum iron, and significantly reduced mean corpuscular volume (P<0.05). Compared with the Hp-negative group, the Hp-positive group had significantly lower levels of hemoglobin, serum ferritin, and serum iron, significantly reduced mean corpuscular volume (P<0.05), and significantly higher incidences of gastrointestinal symptoms, gastrointestinal bleeding, poor nutritional status, and non-steroidal anti-inflammatory drug use (P<0.05). No significant differences were found in hemoglobin, serum ferritin, serum iron, or mean corpuscular volume between the Hp-positive case subgroup and the Hp-negative case subgroup (P>0.05).?Conclusion?Hp infection is closely associated with reduced iron stores and the development of IDA in women of childbearing age. Hp-positive women of childbearing age are more likely to exhibit abnormalities in iron metabolism and gastrointestinal-related clinical indicators.

  Key words: Helicobacter pylori?infection; Women of childbearing age; Iron stores; Iron deficiency anemia

  提交时间：2026-05-29

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• 序号	提交日期	编号	操作
  1	2026-04-03	10.12201/bmr.202605.00103V1	下载

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