通讯作者: 王永吉, wangyjcczyy@163.com

DOI：10.12201/bmr.202605.00090

A Discussion on the Principles of Medicinal Formulation for the Treatment of Pediatric Diarrhea in Traditional Chinese Medicine Based on the *Chinese Medical Canon*

• 摘要：目的：为全面挖掘和总结古籍中小儿腹泻的方药运用规律，对《中华医典》（第5版）小便中治疗小儿腹泻方剂进行数据挖掘。方法：建立统一的方药数据库，采用频数统计、关联规则分析、复杂网络图示、聚类分析等多种方法对数据进行挖掘。结果：共录入规范化方剂396首，涉及到中药320种，药物频次数3226次。高频药物有甘草、白术、茯苓、人参；药性温、寒、平药物占多数，药味辛、甘、苦药物较多，归经集中在脾、胃二经。关联规则挖掘出甘草-陈皮-人参等关联度高的关系核心药对，复杂网络证明核心药物人参、甘草、白术、茯苓与理气化湿药物关系密切。结论：《中华医典》古籍治疗小儿腹泻组方规律充分体现“脾虚湿盛”病因病机，治方基本思路是健脾益气、化湿行气，本研究为现在的配伍方药研发及制剂提供了古典文献和数据支持。

  关键词： 中华医典；小儿腹泻；数据挖掘；用药特点；组方规律; ; ; ; 

   

  Abstract: Objective: To comprehensively explore and summarize the patterns of formula and herbal usage for pediatric diarrhea in classical medical texts, this study conducted data mining on the formulas for treating pediatric diarrhea in the *Chinese Medical Canon* (5th Edition). Methods: A unified database of formulas and herbs was established, and data mining was performed using various methods, including frequency statistics, association rule analysis, complex network visualization, and cluster analysis. Results: A total of 396 standardized formulas were recorded, involving 320 types of Chinese medicinal herbs and 3,226 instances of drug usage. High-frequency herbs included licorice, Atractylodes macrocephala, Poria cocos, and ginseng; herbs with warm, cold, or neutral natures predominated, while those with pungent, sweet, or bitter tastes were more common, and their meridian affinities were concentrated in the Spleen and Stomach meridians. Association rule analysis identified core herb pairs with high association scores, such as licorice-Chenpi-ginseng. Complex network analysis demonstrated that the core herbs—ginseng, licorice, Atractylodes macrocephala, and Poria cocos—were closely related to herbs that regulate qi and resolve dampness. Conclusion: The patterns of formulae for treating pediatric diarrhea in the classical text *The Chinese Medical Canon* fully reflect the pathogenesis of “spleen deficiency with excessive dampness.” The fundamental therapeutic approach involves strengthening the spleen and tonifying qi, as well as transforming dampness and regulating qi. This study provides classical textual and data support for the development of modern herbal formulae and pharmaceutical preparations.

  Key words: The Chinese Medical Canon; Pediatric Diarrhea; Data Mining; Characteristics of Drug Use; Formula Composition Patterns

  提交时间：2026-05-25

  版权声明：作者本人独立拥有该论文的版权，预印本系统仅拥有论文的永久保存权利。任何人未经允许不得重复使用。
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• 序号	提交日期	编号	操作
  1	2026-04-21	10.12201/bmr.202605.00090V1	下载

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