通讯作者: 麦合甫孜·艾山, 1506504160@qq.com

DOI：10.12201/bmr.202604.00021

Research Progress on Metal-Polyphenol Networks Inhibiting Oral Pathogenic Bacteria

• 摘要：口腔细菌感染引发的龋齿、牙周炎等疾病不仅危害口腔健康,更可诱发心血管疾病、糖尿病等全身性病症,已成为全球重大公共卫生问题。传统抗菌手段存在抗生素耐药性、洗必泰着色等局限,亟需开发新型高效抗菌材料。金属-多酚网络(metal-polyphenol networks,MPNs)作为一类由金属离子与多酚配体自组装形成的超分子材料,兼具生物相容性、结构可调性及协同抗菌活性,在口腔致病菌抑制领域展现出巨大应用潜力。本文系统梳理MPNs的组成特性与口腔致病菌的致病机制,重点阐述其抑制口腔细菌的作用机制,总结其在口腔疾病治疗与预防场景中的应用进展,分析当前研究面临的瓶颈并展望未来发展方向,为MPNs基口腔抗菌材料的研发与临床转化提供参考。

  关键词： 金属-多酚网络; 口腔致病菌; 抗菌机制; 口腔生物材料; 协同抗菌

   

  Abstract: Dental diseases caused by oral bacterial infections, such as cavities and periodontitis, not only threaten oral health but can also induce systemic conditions like cardiovascular disease and diabetes through the bloodstream, becoming a major global public health issue. The limitations of traditional antimicrobial approaches, such as antibiotic resistance and staining from chlorhexidine, are increasingly evident, highlighting the urgent need to develop new, efficient antimicrobial materials. Metal-polyphenol networks (MPNs), a class of supramolecular materials self-assembled from metal ions and polyphenol ligands, offer biocompatibility, structural tunability, and synergistic antimicrobial activity, showing great potential in inhibiting oral pathogenic bacteria. This article systematically reviews the composition and characteristics of MPNs and the pathogenic mechanisms of oral pathogenic bacteria, focusing on their mechanisms in inhibiting oral bacteria, summarizing their application progress in the treatment and prevention of oral diseases, analyzing current research bottlenecks, and exploring future development directions, providing a reference for the development and clinical translation of MPN-based oral antimicrobial materials.

  Key words: Metal-polyphenol networks; Oral pathogenic bacteria; Antibacterial mechanisms; Oral biomaterials; Synergistic antibacterial

  提交时间：2026-04-03

  版权声明：作者本人独立拥有该论文的版权，预印本系统仅拥有论文的永久保存权利。任何人未经允许不得重复使用。
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• 序号	提交日期	编号	操作
  1	2026-02-04	10.12201/bmr.202604.00021V1	下载

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