通讯作者: 严峻, yanjun@gxmu.edu.cn

DOI：10.12201/bmr.202604.00009

Association Between the Serum Uric Acid to High-Density Lipoprotein Cholesterol Ratio and the Prevalence of Intracranial Aneurysms

• 摘要：【目的】探讨尿酸/高密度脂蛋白胆固醇比值（uric acid to high-density lipoprotein cholesterol ratio，UHR）与颅内动脉瘤患病风险之间的关联。【方法】纳入颅内动脉瘤患者104例，同期非动脉瘤住院患者97例作为对照。收集人口学特征、生活方式及实验室生化指标。采用多因素Logistic回归分析UHR与颅内动脉瘤的关联，并分别以连续变量和四分位数（Q1～Q4）分组形式纳入模型。采用限制性立方样条（restricted cubic spline，RCS）分析剂量-反应关系，并以受试者工作特征曲线（receiver operating characteristic curve，ROC）评价模型判别能力。【结果】在完全调整模型中，UHR与颅内动脉瘤患病率呈正相关（P<0.05）。按UHR四分位数分组后，与Q1组相比，Q2组颅内动脉瘤患病风险升高（P<0.05），Q3组差异无统计学意义，Q4组呈边缘性差异。ROC分析显示，模型曲线下面积（area under the curve，AUC）由0.541提高至0.712。RCS分析未提示显著非线性关联。【结论】较高UHR与颅内动脉瘤患病率升高相关，可能作为风险评估的辅助指标。

  关键词： 血清尿酸与高密度脂蛋白胆固醇比值; 颅内动脉瘤; 横断面研究; UHR

   

  Abstract: Objective: To investigate the association between the uric acid to high-density lipoprotein cholesterol ratio (UHR) and the prevalence of intracranial aneurysm.Methods: A total of 104 patients with intracranial aneurysm and 97 hospitalized patients without aneurysm during the same period were included as controls. Demographic characteristics, lifestyle factors, and laboratory biochemical parameters were collected. Multivariable logistic regression was performed to assess the association between UHR and intracranial aneurysm, with UHR entered into the models both as a continuous variable and as quartiles (Q1-Q4). Restricted cubic spline (RCS) analysis was used to evaluate the dose-response relationship, and receiver operating characteristic (ROC) curves were used to assess model discrimination.Results: In the fully adjusted model, UHR was positively associated with the prevalence of intracranial aneurysm (P<0.05). When UHR was analyzed by quartiles, compared with the Q1 group, the risk of intracranial aneurysm was increased in the Q2 group (P<0.05), while no statistically significant difference was observed in the Q3 group, and the Q4 group showed a borderline association. ROC analysis showed that the area under the curve (AUC) increased from 0.541 to 0.712. RCS analysis did not indicate a significant nonlinear association.Conclusion: Higher UHR was associated with an increased prevalence of intracranial aneurysm and may serve as an auxiliary indicator for risk assessment.

  Key words: uric acid to high-density lipoprotein cholesterol ratio; intracranial aneurysm; cross-sectional study; UHR

  提交时间：2026-04-02

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• 序号	提交日期	编号	操作
  1	2026-03-12	10.12201/bmr.202604.00009V1	下载

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