通讯作者: 李铁强, 49130762@qq.com

DOI：10.12201/bmr.202603.00023

Observation of Atractylodes and Shengdihuang granules in treating constipation-type Irritable Bowel Syndrome with anxiety state

• 摘要：目的：通过观察白术、生地黄颗粒剂治疗便秘型肠易激综合征（constipation-predominant irritable bowel syndrome，IBS-C）合并焦虑状态的疗效，总结一种有效的中医治疗方案。方法：选择86例诊断为IBS-C合并焦虑状态的患者，将所有患者以随机方式分为观察组与对照组。两组均口服氟哌噻吨美利曲辛片，同时观察组患者给予口服白术、生地黄颗粒剂；对照组给予口服乳果糖溶液。记录两组治疗前后的症状评分、宗氏焦虑评分及血液样本指标的变化，并对比两组的有效率和不良反应发生率。结果：治疗后两组在焦虑评分、5-羟色胺（5-hydroxytryptamine，5-HT）、胃动素（motilin，MOT）和血管活性肠肽（vasoactive intestinal peptide，VIP）均较治疗前有显著差异，两组组间对比积分无显著性差异，表明观察组具有与对照组相当的临床疗效。结论：白术、生地黄颗粒治疗便秘型肠易激综合征合并焦虑状态安全有效，值得临床推广运用。

  关键词： 白术; 生地黄; 肠易激综合征; 便秘; 焦虑状态

   

  Abstract: Abstract:By observing the effects of Atractylodes and Shengdihuang granules in the treatment of constipation-predominant irritable bowel syndrome(IBS-C)and anxiety disorders,and to integrate an effective treatment plan based on traditional Chinese medicine.Methods:Eighty-six patients diagnosed with IBS-C and anxiety disorders were randomly divided into an observation group and a control group.Both groups received oral flupentixol-melitracen tablets,with the observation group additionally taking oral Atractylodes and Shengdihuang granules,while the control group received oral lactulose solution.Symptomatic outcomes,Zung anxiety scale scores,and changes in blood indicators before and after treatment were recorded,and the treatment effects and frequency of side effects were compared between the two groups.Results:After treatment,both groups showed significant changes in anxiety,anxiety scale scores,5-HT,MOT and VIP indicators compared with before treatment,but no significant differences were observed between the groups.Indicating that the observation group has clinical efficacy comparable to the control group.Conclusion:Atractylodes and Shengdihuang granules are safe and effective in treating constipation-predominant irritable bowel syndrome with anxiety,and are worthy of clinical promotion.

  Key words: Astragalus; Shengdihuang granule; Irritable Bowel Syndrome; Constipation; Anxiety state

  提交时间：2026-03-09

  版权声明：作者本人独立拥有该论文的版权，预印本系统仅拥有论文的永久保存权利。任何人未经允许不得重复使用。
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• 序号	提交日期	编号	操作
  1	2026-02-11	10.12201/bmr.202603.00023V1	下载

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