通讯作者: 王起成, 1051485132@qq.com

DOI：10.12201/bmr.202601.00032

Clinical Observation of the Efficacy of Huanglian Moisturizing Ointment in Treating Mild to Moderate Plaque Psoriasis

• 摘要：目的：观察黄连润肌膏轻中度寻常型银屑病的临床疗效,探讨其对血液流变学的影响。方法：采用随机对照的方法,纳入90例门诊患者,随机分为3组。治疗组予黄连润肌膏联合复方氟米松软膏治疗,对照A组予黄连润肌膏治疗,对照B组予复方氟米松乳膏治疗,三组均予依巴斯汀片口服,疗程2周。结果：治疗周期结束后。(1)治疗组总有效率是96.67% (1/30),对照A组总有效率是66.67%(20/30),对照B组总有效率是70.00%(21/30),治疗组疗效优于对照组,差异有统计学意义(p＜0.05),对照B组疗效高于对照A组,差异无统计学意义(p＞0.05)。(2)三组患者PASI评分、瘙痒程度评分、血液流变学指标均较治疗前改善(p＜0.05),三组比较,治疗组改善程度优于对照组,差异具统计学意义(p＜0.05),对照A组与对照B组相比,差异无统计学意义(p＞0.05)。(3)治疗期间,三组患者未发现明显不良反应。(4)三组患者复发率低,但治疗组和对照B组两组相比,差异具有统计学意义(P＜0.05)。结论：黄连润肌膏治疗轻中度寻常型银屑病疗效安全肯定,使用方便,值得基层推广。

  关键词： 黄连润肌膏、复方氟米松软膏、寻常型银屑病、临床疗效、血液流变学

   

  Abstract: Objective: To observe the clinical efficacy of Huanglian Moisturizing Ointment in treating mild to moderate plaque psoriasis and to explore its effects on blood rheology. Methods: A randomized controlled method was adopted, enrolling 90 outpatients who were randomly divided into three groups. The treatment group received Huanglian Moisturizing Ointment combined with Compound Fluocinonide Ointment; Control Group A received Huanglian Moisturizing Ointment; Control Group B received Compound Fluocinonide Cream. All three groups were given oral Ebastine tablets for 2 weeks. Results: At the end of the treatment period: (1) The total effective rate of the treatment group was 96.67% (29/30), Control Group A was 66.67% (20/30), and Control Group B was 70.00% (21/30). The treatment group showed better efficacy than the control groups, with a statistically significant difference (p<0.05). The efficacy of Control Group B was higher than Control Group A, with no statistically significant difference (p>0.05). (2) PASI scores, pruritus severity scores, and blood rheology indicators improved in all three groups compared with before treatment (p<0.05). Among the groups, the treatment group had greater improvement than the control groups, with statistically significant differences (p<0.05), but the difference between Control Group A and Control Group B was not statistically significant (p>0.05). (3) No obvious adverse reactions were observed in any of the groups during the treatment. (4) The recurrence rate was low in all three groups, but the difference between the treatment group and control group B was statistically significant (P < 0.05).Conclusion: Huanglian Moisturizing Ointment is safe and effective for treating mild to moderate plaque psoriasis, is convenient to use, and is worthy of promotion in primary care.

  Key words: Coptis Moisturizing Ointment, Compound Flumethasone Ointment, Plaque Psoriasis, Clinical Efficacy, Hemorheology

  提交时间：2026-01-11

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• 序号	提交日期	编号	操作
  1	2025-12-30	10.12201/bmr.202601.00032V1	下载

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