通讯作者: 黄敏娜, huangminna.1114@163.com

DOI：10.12201/bmr.202512.00045

An Exploration of the Treatment of Cancer-Related Depression Using Classical Formulas Based on the Dynamic Pathogenesis Changes Across Three Stages

• 摘要：肿瘤相关性抑郁目前尚无特效治疗手段,且病机复杂,现代医学对症治疗及中医药常规“疏肝解郁”模式疗效常不理想,所以突破静态病机分型局限是论治的关键。本文构建了肿瘤相关性抑郁的“三期动态病机”模型,并系统梳理其与仲景经方对应关系,初期以小柴胡汤、四逆散疏泄枢机；中期以柴胡加龙骨牡蛎汤、黄连阿胶汤等清补兼施、调和寒热；末期以肾气丸等温阳益精、固守神机,以期为临床提供论治肿瘤相关性抑郁动态精准的辨治策略,为本病诊治提供新思路。

  关键词： 肿瘤相关性抑郁; 郁证; 动态病机; 仲景经方

   

  Abstract: Cancer-related depression currently lacks specific effective treatments and has complex pathogenesis. Both symptomatic treatment in modern medicine and the conventional Chinese medicine approach of soothing the liver and resolving depression often yield unsatisfactory results. Therefore, breaking through the limitations of static pathogenesis classification is crucial for treatment. This paper- establishes a three-stage dynamic pathogenesis model for cancer-related depression and systematically organizes its correspondence with Zhang Zhongjings classical formulas. In the early stage, “Xiaochaihu Tang” and “Sini San” are used to regulate the pivot mechanism and resolve stagnation. In the middle stage, “Chaihu Jia Longgu Muli Tang” and “Huanglian Ejiao Tang” are employed to clear and tonify simultaneously, harmonizing cold and heat. In the late stage, “Shenqi Wan” is applied to warm yang, replenish essence, and consolidate the spirit mechanism. This aims to provide a dynamic and precise treatment strategy for cancer-related depression in clinical practice, offering new insights for the diagnosis and treatment of this condition.

  Key words: Cancer-related depression; Depression pattern; Dynamic pathogenesis; Zhang Zhongjings classical formulas

  提交时间：2025-12-16

  版权声明：作者本人独立拥有该论文的版权，预印本系统仅拥有论文的永久保存权利。任何人未经允许不得重复使用。
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• 序号	提交日期	编号	操作
  1	2025-10-27	10.12201/bmr.202512.00045V1	下载

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