Based on network pharmacology and molecular docking technology to explore the molecular mechanism of Oulongma oral drops in the treatment of allergic rhinitis

Corresponding author: WU Xiayang, 56425477@qq.com

DOI: 10.12201/bmr.202508.00023

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  Abstract: Objective: To predict the target proteins and mechanisms of Ouroboros in treating allergic rhinitis (AR) based on network pharmacology and molecular docking technology. Methods: The BATMAN database was used to screen active components and related targets in Ouroboros oral drops. AR-related disease targets were obtained from multiple disease databases. The String database was utilized to construct a protein-protein interaction (PPI) network and screen core targets. The David platform was employed for gene ontology (GO) functional and Kyoto encyclopedia of genes and genomes (KEGG) pathway enrichment analysis. The CB-Dock2 tool was used for molecular docking to validate the binding capability between key active components and core targets. Results: A total of 252 potential target proteins were screened. Network topology analysis revealed that quercetin, palmitic acid, stearic acid, myristic acid, and lignoceric acid were key active components. PPI network analysis identified STAT3, IL-6, TNF, TP53, and EGFR as core target proteins. GO enrichment analysis primarily showed biological processes such as inflammatory responses and immune regulation, while KEGG pathway enrichment revealed that Ouroboros acts on multiple signaling pathways closely related to AR. Molecular docking results demonstrated strong binding affinity between key active components and core targets, with the binding to TNF and EGFR being the most significant. Conclusion: Ouroboros may target core proteins such as STAT3, IL-6, and TNF through key active components like quercetin, regulating inflammatory and immune response-related signaling pathways to achieve multi-target and multi-pathway therapeutic effects on AR.

  Key words: ; ; ; ; 

  Submit time: 11 August 2025

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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