The effect of inflammation on the outcome of assisted conception in patients with endometriosis

DOI: 10.12201/bmr.202506.00081

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  Abstract: Objective To investigate whether inflammatory indicators have an impact on IVF/ICSI fertility outcomes in their patients with ovarian endometriosis (Ovarian endometriosis (OEM) patients with IVF/ICSI assisted conception outcomes. Methods OEM women who underwent IVF/ICSI treatment at the Reproductive Centre of the Third Affiliated Hospital of Zhengzhou University between 1 January 2019 and 1 February 2024 were selected, including 73 cases in the non-surgical group and 112 cases in the surgical group, to investigate whether there was a difference in inflammatory markers between the two groups and whether it had an impact on the outcome of assisted conception. Results Compared with the OEM group, the surgical group had higher lymphocyte (L) counts, lower platelet-lymphocyte ratio (PLR), and lower carbohydrate antigen 125 (CA125) in the surgical group. The differences were statistically significant (all P>0.05). No statistically significant differences were observed in neutrophil (N) count, platelet (PLT) count, neutrophil-to-lymphocyte ratio (NLR) and systemic immune-inflammation index (SII) between the two groups (all P<0.05). statistical differences (all P<0.05). After correcting for confounders, the effects of L count, PLR, and CA125 on clinical pregnancy rate and live birth rate were not statistically significant; no statistical differences were observed in clinical pregnancy rate and live birth rate between the two groups. Conclusion The surgical group had higher L counts and lower PRL and CA125 compared to the non-surgical group, but these changes did not significantly affect the clinical pregnancy and live birth outcomes of IVF/ICSI-assisted conception in OEM patients.

  Key words: endometriosis; inflammatory markers; in vitro fertilization; sperm injection; clinical pregnancy; live births

  Submit time: 27 June 2025

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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