Progress of Trditional Chinese Medicine Targeting Alveolar Epithelial Cell Senescence in the Treatment of Pulmonary Fibrosis

Corresponding author: Guan Wei, 5246419@qq.com

DOI: 10.12201/bmr.202506.00012

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  Abstract: Pulmonary fibrosis (PF) is a fatal respiratory disease characterized by destruction of alveolar structure and excessive extracellular matrix deposition. Its pathological process is closely related to alveolar epithelial cell senescence. Senescent alveolar epithelial cells drive a vicious cycle of senescence-inflammation-fibrosis through activation of senescence-associated secretory phenotype (SASP), DNA damage response (DDR), and telomere dysfunction, and ultimately leading to irreversible remodeling of the lung parenchyma. Currently, there are still many limitations in Western medicine for the treatment of PF. Chinese medicine shows unique advantages in the treatment of pulmonary fibrosis through multi-target regulation of aging-related signaling network. In this study, we reviewed the pathological mechanisms, multi-target regulation of related pathways, the mutual evidence of Chinese and Western medicine theories, and related experimental studies to provide new ideas for the treatment of pulmonary fibrosis by targeting alveolar epithelial cell senescence.

  Key words: Pulmonary; Fibrosis, Alveolar; Epithelial Cells, Cellular; Senescence, Herbal; Monomers, Herbal; Compounds

  Submit time: 5 June 2025

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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