Research progress on peroxisome proliferator activated receptor γ and systemic lupus erythematosus

Corresponding author: Li Xin, 543679618@qq.com

DOI: 10.12201/bmr.202505.00007

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  Abstract: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with complex clinical manifestations. Because the pathogenesis of this disease is not completely clear, and the individual differences between patients are large, the existing treatment methods are limited. Peroxisome proliferator activated receptor γ (PPAR γ) is the most widely studied member of PPAR subfamily, which is involved in regulating adipocyte differentiation, glucose metabolism, inflammatory response, immune regulation and other life activities. Some recent studies have shown that PPAR γ agonists may be potential drugs for the treatment of SLE. This article reviews the latest research progress of PPAR γ in SLE, aiming to provide new insights and theoretical basis for the treatment of SLE.

  Key words: Peroxisome proliferator activated receptor γ, Systemic lupus erythematosus, Rosiglitazone, Pioglitazone

  Submit time: 11 May 2025

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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