Zhang Hui, Xie Chen. Clinical application study of different doses of remimazolam in ultrasound-guided caudal block for hemorrhoidectomyLIU Tao,Zhang Hui,XIE Chen,Department of Anesthesiology,First People’s Hospital of Huzhou,Huzhou 313000,CHINA. 2024. biomedRxiv.202411.00025
Clinical application study of different doses of remimazolam in ultrasound-guided caudal block for hemorrhoidectomyLIU Tao,Zhang Hui,XIE Chen,Department of Anesthesiology,First People’s Hospital of Huzhou,Huzhou 313000,CHINA
Corresponding author: Xie Chen, hzyyxc@163.com
DOI: 10.12201/bmr.202411.00025
-
Abstract: Objective: To explore the sedative effects of different doses of remimazolam in ultrasound-guided caudal block hemorrhoidectomy and its impact on hemodynamics. Methods: A total of 90 patients undergoing ultrasound-guided caudal block hemorrhoidectomy from June 2023 to May 2024 were selected and randomly divided into three groups (A, B, C), with 30 cases in each group. Remimazolam was administered via intravenous pump at doses of 0.2, 0.3, and 0.5 mg/(kg·h) for sedation. The sedative effects among the three groups were compared, and changes in mean arterial pressure (MAP), heart rate (HR), pulse oxygen saturation (SPO2), and respiratory rate (RR) were recorded at baseline (T0), immediately after administration (T1), during anal dilation (T2), during hemorrhoidectomy (T3), at the end of surgery (T4), and at awakening (T5). The occurrence of adverse reactions in the three groups was also recorded. Results: Compared to group C, groups A and B had shorter sedation awakening times and higher sedation success rates, with statistically significant differences (P < 0.05). Compared to T0, MAP, RR, and SPO2 decreased in all three groups at T1-T4, and HR decreased at T3-T5 (P < 0.05). There were no significant differences in MAP and HR among the three groups (P > 0.05), but significant differences were observed in SPO2 and RR at the same time points (P < 0.05). The incidence of adverse reactions in group C was higher than in groups A and B, with statistically significant differences (P < 0.05). There was no statistically significant difference between groups A and B (P > 0.05). Conclusion: Remimazolam provides satisfactory sedation in ultrasound-guided caudal block hemorrhoidectomy, has minimal impact on hemodynamics, and is safe, with a recommended optimal dose of 0.3 mg/(kg·h).
Keywords:Remimazolam; ultrasound-guided; caudal block; hemorrhoidectomy; sedative effectKey words: Remimazolam; ultrasound-guided; caudal block; hemorrhoidectomy; sedative effectSubmit time: 11 November 2024
Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity. -
图表
-
Zhang Xufeng, Yang Xinxia. Application of flipped classroom combined reinforcement training in ultrasound-guided brachial plexus nerve teaching. 2024. doi: 10.12201/bmr.202409.00003
liujing, panyaweng, rengzheng. Progress in robotic thyroidectomy in the treatment of thyroid cancer. 2024. doi: 10.12201/bmr.202411.00030
zhouyibo, wangxidan, chenjingwan, chenfuhua, taoxiaoying. YANG Daoling, ZHOU Yibo, WANG Xidan, CHEN Jingwan, CHEN Fuhua, TAO XiaoyingFirst-author’s address: Department of Ultrasound Medicine, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, 321000, China. 2024. doi: 10.12201/bmr.202410.00076
Zhang Wenxuan, Zhang Feng, Jian Zhaocheng, Luo Qian. Application of PDCA cycle in standardized training of resident doctors in Department of ultrasoundApplication of PDCA cycle in standardized training of resident doctors in Department of ultrasound. 2024. doi: 10.12201/bmr.202411.00021
Qian LI Hai, kong xianghai. The Application Value of Musculoskeletal Ultrasound Combined with Contrast-Enhanced Ultrasound in the Diagnosis of Rotator Cuff Tears. 2024. doi: 10.12201/bmr.202411.00050
liu yanzhao, liu dong. Application of block chain technology in the management of public hospitals in China under COVID-19. 2020. doi: 10.12201/bmr.202003.00070
Observation on the effect and nursing of endoscopic surgery for parotid gland tumors via the postauricular hairline approach. 2024. doi: 10.12201/bmr.202410.00072
XIAO Lan-feng. Progress in the application of intrapartum ultrasound in labor management. 2024. doi: 10.12201/bmr.202409.00042
ZHAO Qing, JING Jiangxin. Advances in the application of ultrasound-based radiomics in predicting molecular typing of breast cancer. 2024. doi: 10.12201/bmr.202410.00040
Construction of CPC case Bank and Its application in Clinical Pathology Teaching of Medical undergraduates. 2024. doi: 10.12201/bmr.202411.00017
-
ID Submit time Number Download 1 2024-10-28 bmr.202411.00025V1
Download -
-
Public Anonymous To author only
Get Citation
Article Metrics
- Read: 83
- Download: 0
- Comment: 0