The value of serum GP73 combined with prognostic nutritional index in the assessment of prognosis after TACE in HCC patients

DOI: 10.12201/bmr.202409.00043

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  Abstract: 【】Objective To investigate the value of serum Golgi protein 73 (GP73) combined with prognostic nutritional index (PNI) in assessing the prognosis of patients with hepatocellular carcinoma (HCC) after transcatheter arterial chemoembolization (TACE). Methods 231 HCC patients who underwent TACE in our hospital from January 2020 to January 2023 (HCC group) and 120 physically examined healthy people in the same time period (control group) were selected, and the HCC patients were divided into a poor prognosis group (81 patients) and a good prognosis group (150 patients) according to the 1-year prognosis (tumor progression or death) after TACE, and the GP73 was detected and the PNI was calculated. A multifactorial unconditional logistic regression model was established to analyze the influencing factors with TACE postoperative prognosis of HCC patients as the dependent variable, and ROC curves were plotted to evaluate the value of serum GP73 combined with PNI in assessing the poor postoperative prognosis of TACE in HCC patients. Results Compared with the control group, serum GP73 level was increased and PNI was decreased in the HCC group (P＜0.05). At 1-year follow-up, the incidence of poor prognosis after TACE in 231 HCC patients was 35.06% (81/231). Compared with the good prognosis group, the serum GP73 level was increased and PNI was decreased in the poor prognosis group (P＜0.05). Child-Pugh classification grade B, Chinese liver cancer stage IIIa, vascular invasion, and high GP73 were independent risk factors for poor prognosis after TACE in HCC patients, and high PNI was an independent protective factor (P＜0.05). The area under the curve of serum GP73 combined with PNI for assessing poor prognosis after TACE in patients with HCC was 0.870, which was greater than that of serum GP73 and PNI levels assessed alone, which were 0.784 and 0.790 (P＜0.05). Conclusion Elevated serum GP73 levels and reduced PNI in HCC patients are independent influences on poor prognosis after TACE, and serum GP73 combined with PNI has a high value in assessing poor prognosis after TACE in HCC patients.

  Key words: [keywords missed]

  Submit time: 22 September 2024

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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