74例成人炎性肌成纤维细胞瘤的临床病理分析与治疗

Corresponding author: xiang wang, wangxiang5123@126.com; yajuan shao, ShaoYJ@pumch.cn

DOI: 10.12201/bmr.202408.00018

•  

  Abstract: Objective: Inflammatory myofibroblastic tumor (IMT) is a rare mesenchymal neoplasm with diverse behaviors occurring in soft tissues and visceral organs. The clinical and pathological features of IMT in adult patients are not well understood. This study highlights the importance of comprehensive diagnostics, including histopathology, immunohistochemistry, and genetic testing, in managing IMTs. High ALK positivity in lung IMTs suggests targeted therapies' benefit. ALK inhibitors should be considered for ALK-positive tumors. Regular follow-up is crucial due to relapse risk. Methods: We conducted a retrospective analysis of 74 patients diagnosed with IMTs at Peking Union Medical College Hospital between 2010 and 2023. Clinicopathological data, treatments, and outcomes were collected and analyzed. Results: Among the 74 patients (34 females, 40 males) at an average age of 50, the majority were asymptomatic. The most common tumor locations were the head and neck (24.1%), followed by lung (21.6%). Anaplastic lymphoma kinase (ALK) positivity was identified in 31% of cases, with the highest prevalence in lung IMTs (45.5%). Most patients underwent surgical resection, and some received postoperative treatments including radiotherapy, chemotherapy, or ALK inhibitors. The 1-year, 3-year, 5-year, and 10-year OS rates were 78.4%, 70.9%, 69.2%, and 69.2%，respectively. Limitations: This is a single-center retrospective study, and the characteristics of these patients may not be representative of all adult IMT patients. While the sample size of drug-treated patients is relatively small and heterogeneous, making further systematic analysis difficult. The mechanism of resistance to ALK inhibitors has not been determined. Conclusions: IMTs exhibit significant clinical heterogeneity, with lung IMTs demonstrated the highest rate of ALK positivity. While surgical resection remains the primary treatment modality, the observed rates of relapse and mortality underscore the necessity for more effective therapeutic strategies. ALK inhibitor such as crizotinib should be consideration for ALK positive patients. A deeper understanding of the molecular characteristics of IMTs may help to enhance diagnostic accuracy and inform the development of improved treatment options.

  Key words: Inflammatory myofibroblastic tumors; Clinicalpathological; Anaplastic lymphoma kinase; prognosis

  Submit time: 15 August 2024

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
• html

• 图表

• 孟. Advances in deep learning-based Artificial Intelligence techniques in gastrointestinal stromal tumors.. 2024. doi: 10.12201/bmr.202411.00057

  Construction of CPC case Bank and Its application in Clinical Pathology Teaching of Medical undergraduates. 2024. doi: 10.12201/bmr.202411.00017

  ZHANG Xiaoling, CHEN Kun. The value of systemic inflammatory response index, lactate dehydrogenase and glutamic oxalacetic transaminase in identifying the high-risk population of adult fulminant myocarditis. 2024. doi: 10.12201/bmr.202410.00070

  Cai Xudong. Macrophage Polarization Affects Chronic Kidney Disease:Based on Theory of “Harmful Hyperactivity and Responding Inhibition”. 2024. doi: 10.12201/bmr.202407.00027

  Zeng Wen-Mei, Zheng Yue, Li Yi-Min. Relationship of Human Neutrophil Peptides with the severity and prognosis of Acute Respiratory Distress Syndrome. 2024. doi: 10.12201/bmr.202410.00060

  Liu hongping, Yang Jie, Pang Guoming, Xing Ying, LI Penghui, Wu Ming, Wen XXiaoxiao, Li Hongjiao, Wen Tiancai. 基于改进关联规则与Logistic回归算法集成的2型糖尿病中医证型鉴别研究. 2024. doi: 10.12201/bmr.202404.00034

  zoubaohua, doccong. Prevalence of symptoms of cancer patients and Feasibility of Patient Diary Tool (PDT): a prospective, multi-center, pilot study. 2024. doi: 10.12201/bmr.202404.00040

  Ning nan, Liu Chaowu. Research progress on acupuncture regulation of asthma kinase related pathways. 2024. doi: 10.12201/bmr.202411.00054

  liushunlin. The expression of CPNE1 and ZWILCH in the progression of lung adenocarcinoma and their correlation with prognosis. 2024. doi: 10.12201/bmr.202406.00030

  邹倩, Chen Meihua, Zhang Zhidi. A study of factors influencing dyadic coping in young and middle-aged patients with malignant lymphoma. 2024. doi: 10.12201/bmr.202410.00013

• ID	Submit time	Number	Download
  1	2024-08-09	bmr.202408.00018V1	Download

• Public  Anonymous  To author only Submit Comments