Current application and prognostic value of retroperitoneal lymphadenectomy in patients with low-grade serous ovarian cancer

Corresponding author: chenjieping, chenjp@sysucc.org.cn

DOI: 10.12201/bmr.202610.00001

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  Abstract: Objective: This study aimed to evaluate the current clinical application and prognostic value of retroperitoneal lymphadenectomy (RLND) in patients with low-grade serous ovarian cancer (LGSOC).Methods: We retrospectively reviewed the clinical data of patients with LGSOC who underwent surgical treatment at our institution between January 2010 and December 2023. Cox proportional hazards regression model was utilized to calculate hazard ratios (HRs) and 95% confidence intervals (CIs).Results: LGSOC accounted for 3.2% of all ovarian malignancies treated at our center. Among the included cohort, 51.4% underwent systematic RLND, 17.1% received non-systematic RLND, and 31.4% did not undergo lymphadenectomy. In patients who underwent RLND, the overall rate of lymph node metastasis was 50%, with pelvic and para-aortic lymph node involvement rates of 37.5% and 31.3%, respectively. Patients who underwent systematic RLND and those without lymph node metastasis demonstrated significantly improved survival outcomes. Univariate and multivariate analyses identified primary debulking surgery (HR = 0.289, 95% CI: 0.116–0.720, P < 0.05) and RLND (HR = 0.246, 95% CI: 0.098–0.616, P < 0.05) as independent prognostic factors for overall survival (OS).Conclusion: LGSOC is characterized by a high incidence of lymph node metastasis. RLND is associated with prolonged survival outcomes in patients with LGSOC and serves as an independent prognostic factor for overall survival.

  Key words: Retroperitoneal lymphadenectomy; Lymph node metastasis; Low-grade serous ovarian cancer; Primary debulking surgery; Prognosis

  Submit time: 1 October 2026

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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