通讯作者: 陈洁平, chenjp@sysucc.org.cn

DOI：10.12201/bmr.202610.00001

Current application and prognostic value of retroperitoneal lymphadenectomy in patients with low-grade serous ovarian cancer

• 摘要：目的:本研究拟探讨腹膜后淋巴结切除术(RLND)在卵巢低级别浆液性癌中的应用现状和预后价值。方法:回顾性分析2010年1月至2023年12月经手术治疗的卵巢低级别浆液性癌患者的病例资料。采用Cox比例风险回归模型计算风险比（HR）及其95%置信区间（CI）。结果:卵巢低级别浆液性癌占本中心卵巢恶性肿瘤患者的3.2%。最终纳入研究的患者中，51.4%的患者行系统性RLND，17.1%接受非系统性RLND，31.4%的患者未行淋巴结切除。在接受RLND的患者中，淋巴结转移率为50.0%，盆腔和腹主动脉旁淋巴结转移率分别为37.5%和31.3%；系统性RLND组和无淋巴结转移的患者生存时间更长。单因素及多因素分析显示，直接手术（HR=0.289，95% CI:0.116～0.720，P<0.05）和腹膜后淋巴结切除术（HR=0.246，95% CI:0.098～0.616，P<0.05）均为总生存期的独立预后因素。结论:卵巢低级别浆液性癌的淋巴结转移率较高，淋巴结切除术与更长的卵巢低级别浆液性癌患者的生存时间相关，并且是影响生存的独立因素。

  关键词： 腹膜后淋巴结切除术; 淋巴结转移; 卵巢癌; 初次肿瘤细胞减灭术; 预后

   

  Abstract: Objective: This study aimed to evaluate the current clinical application and prognostic value of retroperitoneal lymphadenectomy (RLND) in patients with low-grade serous ovarian cancer (LGSOC).Methods: We retrospectively reviewed the clinical data of patients with LGSOC who underwent surgical treatment at our institution between January 2010 and December 2023. Cox proportional hazards regression model was utilized to calculate hazard ratios (HRs) and 95% confidence intervals (CIs).Results: LGSOC accounted for 3.2% of all ovarian malignancies treated at our center. Among the included cohort, 51.4% underwent systematic RLND, 17.1% received non-systematic RLND, and 31.4% did not undergo lymphadenectomy. In patients who underwent RLND, the overall rate of lymph node metastasis was 50%, with pelvic and para-aortic lymph node involvement rates of 37.5% and 31.3%, respectively. Patients who underwent systematic RLND and those without lymph node metastasis demonstrated significantly improved survival outcomes. Univariate and multivariate analyses identified primary debulking surgery (HR = 0.289, 95% CI: 0.116–0.720, P < 0.05) and RLND (HR = 0.246, 95% CI: 0.098–0.616, P < 0.05) as independent prognostic factors for overall survival (OS).Conclusion: LGSOC is characterized by a high incidence of lymph node metastasis. RLND is associated with prolonged survival outcomes in patients with LGSOC and serves as an independent prognostic factor for overall survival.

  Key words: Retroperitoneal lymphadenectomy; Lymph node metastasis; Low-grade serous ovarian cancer; Primary debulking surgery; Prognosis

  提交时间：2026-10-01

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• 序号	提交日期	编号	操作
  1	2026-09-13	10.12201/bmr.202610.00001V1	下载

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