Clinical Value of Dyclonine Hydrochloride Mucilage-assisted Colonoscopy: A Systematic Review and Meta-analysis

Corresponding author: Jiang Wenhao

DOI: 10.12201/bmr.202609.00029

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  Abstract: Objective To systematically evaluate the clinical efficacy and safety of dicyclomine hydrochloride mucilage as an adjunct to colonoscopy.Methods PubMed, Embase, Cochrane Library, Web of Science, CNKI, VIP, Wanfang Data, and the Chinese Biomedical Literature Database were searched for relevant randomized controlled trials (RCTs) published from January 2016 to July 2026. Two researchers independently screened the literature and extracted data. Meta-analysis was performed using RevMan 5.4 and Stata 17.0. Results Fourteen RCTs involving 4,404 patients were included. Compared with the control group, dicyclomine hydrochloride mucilage significantly improved defoaming efficacy (RR=1.25, 95% CI: 1.13–1.40, P<0.001), shortened colonoscopy time (MD=-3.61, 95% CI: -5.35 to -1.87, P<0.001), and reduced the risk of abdominal distension (RR=0.19, 95% CI: 0.09–0.40, P<0.001). No significant differences were observed between the two groups in BBPS scores (MD=0.66, 95% CI: -0.34 to 1.67, P>0.05) or the incidence of adverse events (RR=0.88, 95% CI: 0.64–1.21, P>0.05). Sensitivity analyses yielded relatively stable results, and no significant publication bias was detected.Conclusion Dicyclomine hydrochloride mucilage as an adjunct to colonoscopy may improve defoaming efficacy, shorten examination time, and reduce the incidence of abdominal distension, with a favorable safety profile. However, given the heterogeneity observed in some outcomes, further high-quality studies are warranted to confirm these findings.

  Key words: Dyclonine hydrochloride mucilage; Colonoscopy; Bowel preparation; Defoaming effect; Meta-analysis

  Submit time: 21 September 2026

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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