Analysis of the healing effectand safety of Guyuling capsules combined with teriparatide in the treatment of postmenopausal osteoporosis

DOI: 10.12201/bmr.202607.00002

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  Abstract: To investigate the healing effect and safety of Guyuling capsules combined with teriparatide in the treatment of postmenopausal osteoporosis, and analyze the synergistic effect of their combined treatment.Methods: The clinical data of 84 cases of postmenopausal osteoporosis treated in our hospital from December 2019 to January 2024 were collected and analyzed retrospectively. According to the treatment methods, they were divided into routine group and combined group, with 42 patients in each group.The conventional group was treated with teriparatide, while the combined group was treated with Guyuling capsules in combination with teriparatide.The bone density, bone metabolism indicators, Chinese medicine syndrome scores, healing effect, and safety of the two groups were compared.Results: After treatment, the bone densities of lumbar vertebrae L1-4 （t/P=6.057/0.000）and total hip （t/P=2.389/0.019）in the combined group were obviously higher than those in the conventional group (P<0.05).After treatment, combined group and conventional group（lumbar vertebrae L1-4: t/P=22.771/0.000、total hip: t/P=10.241/0.000）showed a obvious increase in bone density compared to before treatment (P<0.05).After treatment, the combined group showed a obvious decrease in bone glaprotein(BGP) （t/P=7.776/0.007） and type I collagen carboxy-terminal peptide (β-CTX) （t/P=9.555/0.000） compared to the conventional group (P<0.05).After treatment, combined group and conventional group showed obvious reductions in BGP （t/P=61.220/0.000、t/P=50.827/0.000）and β-CTX （t/P=44.508/0.000、t/P=18.433/0.000）compared to before treatment (P<0.05).After treatment, the TCM syndrome scores of the combined group （t/P=4.993/0.000）were obviously lower than those of the conventional group (P<0.05), and combined group and conventional group （t/P=21.584/0.000、t/P=16.285/0.000）showed a obvious decrease in TCM syndrome scores after treatment compared to before treatment (P<0.05).The total effective rate of the combined group was obviously higher than that of the conventional group （χ2/P=4.941/0.026）.There was no obvious difference in the overall incidence of adverse reactions between the combined group and the conventional group （χ2/P=0.553/0.457）.Conclusion: The combination of Guyuling capsules and teriparatide has a good healing effect on postmenopausal osteoporosis. It can improve bone density, bone metabolism, and has high safety.

  Key words: postmenopausal osteoporosis; Guyuling capsules; teriparatide; healing effect; safety

  Submit time: 1 July 2026

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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