Clinical Study on Modified Erzhi Wan in Assisting the Improvement of Postoperative Efficacy in Patients with Rotator Cuff Tear Complicated by PMOP

DOI: 10.12201/bmr.202512.00073

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  Abstract: Objective To observe the efficacy and safety of modified Erzhi Wan in adjuvantly improving the postoperative outcomes of patients with chronic rotator cuff injury complicated by PMOP. Methods This study enrolled 68 patients with chronic rotator cuff injury complicated by PMOP who were hospitalized in our hospital and underwent arthroscopic rotator cuff repair between June 2024 and March 2025. The patients were divided into an observation group and a control group using a random number table method, with 34 cases in each group. The control group received conventional oral administration of Calcium Carbonate D3 Tablets and Alfacalcidol Soft Capsules for anti-osteoporosis treatment after surgery. The observation group was given modified Erzhi Wan on the basis of the treatment received by the control group. Both groups received intervention for 12 weeks after surgery. TCM syndrome score, VAS score, ASES score, SF-36 score, and BMD of the greater tuberosity of the humerus were recorded before surgery and at 12 weeks after surgery. Ultrasonic observation results were documented at 1 week and 12 weeks after surgery, and adverse reactions during the medication period were also recorded. Results Both groups of patients completed a 12-week follow-up. Before surgery, there were no statistically significant differences between the two groups in terms of TCM score, VAS score, ASES score, SF-36 score, and BMD of the greater tuberosity of the humerus(P>0.05). One week after surgery, there was no statistically significant difference in the ultrasound observation results between the two groups (P>0.05). At 12 weeks after surgery, the TCM score and VAS score of the observation group werelowerthan those of the control group, while the ASES score and SF-36 score werehigherthan those of the control group; all these differences were statistically significant (P＜0.05). There was no statistically significant difference in the BMD of the greater tuberosity of the humerus between the two groups (P>0.05). TheSugaya classificationof the observation group was better than that of the control group, thesubacromial effusionwas less than that of the control group, and thesliding distance ratio of the supraspinatus tendonwas higher than that of the control group; all these differences were statistically significant (P＜0.05). Conclusion When used as an adjuvant therapy for patients with chronic rotator cuff injury complicated by PMOP after rotator cuff repair surgery, modified Erzhi Wan can effectively alleviate local inflammatory responses, reduce the patients pain level, improve motor function and quality of life, with good safety.

  Key words: Erzhi Wan; Rotator Cuff Injury; PMOP; Ultrasound; Bone Mineral Density

  Submit time: 28 December 2025

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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