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Corresponding author: zhao si lin, 270315298@qq.com

DOI: 10.12201/bmr.202602.00043

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  Abstract: (1.Hunan University of Chinese Medicine, Hunan Changsha 410208, China；2.The First Clinical Medical College of Hunan University of Chinese Medicine,Hunan Changsha 410007,China) Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive interstitial lung disease of unknown cause, and its pathological evolution highly aligns with the transformation from lung paralysis to lung wither in traditional Chinese medicine. The theory of restraining excessiveness to acquire harmony reveals the dynamic balance between the harm caused by excess and restraint and repair under pathological conditions in the human body. Based on this, the traditional Chinese medicine pathogenesis of IPF is analyzed, and its disease course is divided into three stages: the Lung Paralysis and Excess-Harm Stage, the Transition from Paralysis to Withering Stage, and the Lung Wither and Regulation-Collapse Stage. A stepwise treatment strategy of Reducing Excess, Restoring Balance, and Reinforcing the Foundation is systematically proposed: the first focuses on eliminating pathogens while facilitating regulation; the second on harmonizing restraint and repair by combining attack and tonification; and the third on consolidating the root to rescue the system and maintain residual regulatory function. This provides a new perspective for the traditional Chinese medicine diagnosis and treatment of this disease.

  Key words: idiopathic pulmonary fibrosis; restraining excessiveness to acquire harmony; staging treatment; lung paralysis; lung wither

  Submit time: 11 February 2026

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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  1	2026-01-28	10.12201/bmr.202602.00043V1	Download

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