The Efficacy of Traditional Chinese Medicine Therapy in Improving the Clinical Symptoms of Hyperuricemia：A Network Meta-analysis

Corresponding author: Fanmingming, fanmingming2025ok@163.com

DOI: 10.12201/bmr.202601.00029

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  Abstract: Abstract　Objective: Evaluate the efficacy of various traditional Chinese medicine therapies in improving the clinical symptoms of hyperuricemia. Methods: Cochrane Library, PubMed, CNKI, Wanfang Data Knowledge Service Platform, CQ VIP, China Biomedical Literature Database were searched to look for randomised controlled trials (RCT) of TCM interventions to improve symptoms of hyperuricemia published from January 2014 to July 2024. Two investigators independently screened the literature, extracted data, and evaluated the risk of bias of the included literature using the RCT bias risk assessment tool recommended by the Cochrane Manual of Systematic Review 5.3. Bayesian network meta-analysis was performed on the overall response rate for improvement in hyperuricemia symptoms, blood uric acid levels, and improvement in medical syndrome scores in patients under different interventions by using R 4.2.2 software and Stata16 software. Results: A total of 42 randomized controlled trials, including 3504 patients, involving a total of 9 TCM interventions were included (decoction, medicinal tea, acupuncture, catgut embedding, enema, life nurturing, kinesiatrics, massage, electroacupuncture). The results of the network meta-analysis showed that catgut embedding was the most likely to be the best intervention in improving blood uric acid levels; In terms of improving TCM syndrome scores, Chinese herbal decoctions are the most likely to be the best intervention; In terms of overall effectiveness in improving clinical symptoms of hyperuricemia, catgut embedding is the most likely to be the best intervention. Conclusion: Catgut embedding has significant advantages in improving the total efficiency and blood uric acid level of clinical symptoms of hyperuricemia and Chinese medicine decoction has significant advantages in improving the medical syndrome score of hyperuricemia patients. However, more high-quality studies are needed to further validate this conclusion. Key words: Hyperuricemia; Traditional Chinese medicine therapy; Network Meta-analysis; Randomised controlled trials; Blood uric acid

  Key words: Hyperuricemia; Traditional Chinese medicine therapy; Network Meta-analysis; Randomised controlled trials; Blood uric acid

  Submit time: 11 January 2026

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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