Study on the Theory and Application of “Heart-Gallbladder Interconnection”

Corresponding author: Chongyang Ma, machongyang@live.com

DOI: 10.12201/bmr.202512.00035

•  

  Abstract: The theory of Heart-Gallbladder Interconnection originates from the Theory of Visceral Interconnection, revealing the close relationship between the heart and gallbladder in both physiology and pathology. Physiologically, the heart governing mental activities and the gallbladder controlling decision-making jointly regulate consciousness, with the monarch fire (heart) and ministerial fire (gallbladder) working synergistically, connected through the ocular system and pericardium meridians. Pathologically, bidirectional transmission occurs: heart disease may affect the gallbladder, while gallbladder disorders often disturb heart function, clinically manifesting as palpitations and hypochondriac pain. Modern research has confirmed its scientific basis, including the gallbladder-heart reflex pathway, high comorbidity between gallbladder and cardiovascular diseases, and established causal relationships in gallbladder-heart syndrome. Clinical applications demonstrate the theorys value: Wendan Decoction treats depression, coronary heart disease, and schizophrenia; Gualou Xiebai Banxia Decoction effectively manages chronic cholecystitis. This theory not only enriches TCM visceral manifestation theory but also provides new perspectives for modern medicine with its holistic approach, holding significant theoretical and clinical value.

  Key words: heart; gallbladder; visceral interconnection; heart-gallbladder interconnection; gallbladder-heart syndrome

  Submit time: 12 December 2025

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
• html

• 图表

• The levels and diagnostic value of serum CC16 and Klotho in elderly patients with coronary heart disease complicated with frailty syndrome. 2025. doi: 10.12201/bmr.202511.00011

  Xu Ping¹. Exploration of Treatment Experience for Pediatric Atopic Dermatitis Based on Heart and Spleen Theory. 2024. doi: 10.12201/bmr.202412.00043

  Li Yaping. Clinical Observation on the Treatment of Perimenopausal Insomnia of the Heart-kidney Disharmony Type by Regulating the Spirit and Nourishing the Heart Tang. 2024. doi: 10.12201/bmr.202408.00031

  YANG Qing. Clinical Observation of Qinggan Ningxin Zhidong Prescription in the Treatment of Attention Deficit Hyperactivity Disorder with Heart-Liver Fire Blazing Syndrome. 2024. doi: 10.12201/bmr.202412.00051

  李明峻, Zhai Ning. Advances and prospects of artificial intelligence in precision phenotyping of heart failure. 2025. doi: 10.12201/bmr.202512.00030

  HEXin, matiantian, yuanyuepeng, zhuyuanheng, xuyiguo, wangweilong. Exploration of the pathogenesis of vascular depression based on the theory of heart-brain homoeopathy in the treatment of vascular depressionLU Caiju1,HE Xin1,YUAN Yuepeng2,MA Tiantian1,ZHU Yuanheng1,XU Yiguo2,WANG Weilong2. 2025. doi: 10.12201/bmr.202507.00080

  SHENG Xuehui, CHEN Feng. Evaluation of the Clinical Efficacy of Press-Needle Therapy Combined with Conventional Treatment for Heart Failure. 2025. doi: 10.12201/bmr.202511.00004

  The impact of evidence-based nutritional care on disease outcomes in patients with severe heart failure. 2025. doi: 10.12201/bmr.202503.00018

  LI Yi-mei. Advances in clinical research of heart rate variability for chronic pain. 2024. doi: 10.12201/bmr.202410.00065

  Chen Yuan, Chen Shiqi, Zhang Rongxiang, Zhu Chenyang. Meta-analysis of the effects of ERAS in the perioperative period in patients with heart valve disease. 2024. doi: 10.12201/bmr.202410.00008

• ID	Submit time	Number	Download
  1	2025-10-21	10.12201/bmr.202512.00035V1	Download

• Public  Anonymous  To author only Submit Comments