The levels and diagnostic value of serum CC16 and Klotho in elderly patients with coronary heart disease complicated with frailty syndrome

DOI: 10.12201/bmr.202511.00011

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  Abstract: Objective To explore the levels and diagnostic value of serum Clara cell protein (CC16) and Klotho in elderly patients with coronary heart disease (CHD) complicated with frailty syndrome. Methods From August 2021 to June 2023, 295 CHD patients admitted were selected and separated into a frailty group and a non frailty group based on the presence or absence of frailty syndrome. ELISA was used to detect serum CC16 and Klotho levels. Pearson method was used to explore the correlation between serum CC16, Klotho levels, and inflammatory markers in the frailty group. Logistic method was used to explore the influencing factors of frailty syndrome in elderly CHD patients. In addition, receiver operating characteristic (ROC) curve was used to analyze the value of serum CC16 and Klotho in diagnosing frailty syndrome in elderly CHD patients. Results Compared with the non frailty group, the frailty group had clearly lower serum CC16 and Klotho (P<0.05), and clearly higher nuclear factor kappa-B (NF-κB), tumor necrosis factor α (TNF-α), and interleukins 6 (IL-6) (P<0.05). According to Pearson correlation analysis, serum CC16 was positively correlated with Klotho (P<0.05), and both were negatively correlated with NF-κB, TNF-α, and IL-6 (P<0.05). Serum CC16 and Klotho decreased sequentially in the mild, moderate, and severe groups, while NF-κB, TNF-α, and IL-6 increased sequentially (P<0.05). According to logistic analysis, age, CCI index, sarcopenia, NF-κB, TNF-α, and IL-6 were risk factors for frailty syndrome in elderly CHD patients (P<0.05), while CC16 and Klotho were protective factors (P<0.05). ROC curve showed that the area under curve (AUC) values of serum CC16 and Klotho alone and their combination for diagnosing frailty syndrome in elderly CHD patients were 0.839, 0.819, and 0.907, respectively. The AUC of combined diagnosis was higher than that of individual diagnosis (Z=2.715, Z=2.726, P<0.05). Conclusion Serum CC16 and Klotho are reduced in elderly patients with CHD complicated with frailty syndrome. The combined detection of the two has certain diagnostic value for patients with CHD complicated with frailty syndrome.Keywords Coronary heart disease; Frailty syndrome; Clara cell protein; Klotho; diagnosis

  Key words: coronary heart disease; frailty syndrome; Clara cell protein; Klotho; diagnosis

  Submit time: 7 November 2025

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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