通讯作者: 汪聪玲, 15088929162@163.com

DOI：10.12201/bmr.202511.00011

The levels and diagnostic value of serum CC16 and Klotho in elderly patients with coronary heart disease complicated with frailty syndrome

• 摘要：目的 探讨老年冠心病（coronary heart disease，CHD）合并衰弱综合征患者血清Clara细胞蛋白（clara cell secretory protein，CC16）、Klotho水平及其诊断价值。方法 选取2021年8月-2023年6月收治的295例CHD患者，根据患者有无衰弱综合征分为衰弱组和未衰弱组。ELISA检测血清CC16、Klotho水平；Pearson法分析衰弱组血清CC16、Klotho水平和炎症指标的相关性；采用Logistic分析老年CHD患者合并衰弱综合征的影响因素；受试者工作特征（receiver operating characteristic，ROC）曲线分析血清CC16、Klotho诊断老年CHD患者合并衰弱综合征的价值。结果 与未衰弱组相比，衰弱组血清CC16、Klotho水平明显降低（P<0.05），核因子-κB（nuclear factor kappa-B，NF-κB）、肿瘤坏死因子-α（tumor necrosis factor α，TNF-α）、白细胞介素-6（interleukins 6，IL-6）水平明显升高（P<0.05）。根据Pearson相关性显示，血清CC16与Klotho呈正相关（P＜0.05），二者均与NF-κB、TNF-α、IL-6呈负相关（P＜0.05）。轻、中和重度组血清CC16、Klotho水平依次降低，NF-κB、TNF-α、IL-6水平依次升高（P＜0.05）。根据Logistic分析显示，年龄、CCI指数、肌少症、NF-κB、TNF-α、IL-6为老年CHD患者合并衰弱综合征的危险因素（P＜0.05），CC16、Klotho为保护因素（P＜0.05）。ROC曲线显示：血清CC16、Klotho单独及联合诊断老年CHD患者合并衰弱综合征的曲线下面积（area under curve，AUC）为0.839、0.819、0.907，联合诊断的AUC高于各自单独诊断（Z=2.715、Z=2.726，P＜0.05）。结论 老年CHD合并衰弱综合征患者血清CC16、Klotho水平均降低，二者联合检测对CHD患者合并衰弱综合征有一定的诊断价值。

  关键词： 冠心病；衰弱综合征；Clara细胞蛋白；Klotho；诊断; ; ; ; 

   

  Abstract: Objective To explore the levels and diagnostic value of serum Clara cell protein (CC16) and Klotho in elderly patients with coronary heart disease (CHD) complicated with frailty syndrome. Methods From August 2021 to June 2023, 295 CHD patients admitted were selected and separated into a frailty group and a non frailty group based on the presence or absence of frailty syndrome. ELISA was used to detect serum CC16 and Klotho levels. Pearson method was used to explore the correlation between serum CC16, Klotho levels, and inflammatory markers in the frailty group. Logistic method was used to explore the influencing factors of frailty syndrome in elderly CHD patients. In addition, receiver operating characteristic (ROC) curve was used to analyze the value of serum CC16 and Klotho in diagnosing frailty syndrome in elderly CHD patients. Results Compared with the non frailty group, the frailty group had clearly lower serum CC16 and Klotho (P<0.05), and clearly higher nuclear factor kappa-B (NF-κB), tumor necrosis factor α (TNF-α), and interleukins 6 (IL-6) (P<0.05). According to Pearson correlation analysis, serum CC16 was positively correlated with Klotho (P<0.05), and both were negatively correlated with NF-κB, TNF-α, and IL-6 (P<0.05). Serum CC16 and Klotho decreased sequentially in the mild, moderate, and severe groups, while NF-κB, TNF-α, and IL-6 increased sequentially (P<0.05). According to logistic analysis, age, CCI index, sarcopenia, NF-κB, TNF-α, and IL-6 were risk factors for frailty syndrome in elderly CHD patients (P<0.05), while CC16 and Klotho were protective factors (P<0.05). ROC curve showed that the area under curve (AUC) values of serum CC16 and Klotho alone and their combination for diagnosing frailty syndrome in elderly CHD patients were 0.839, 0.819, and 0.907, respectively. The AUC of combined diagnosis was higher than that of individual diagnosis (Z=2.715, Z=2.726, P<0.05). Conclusion Serum CC16 and Klotho are reduced in elderly patients with CHD complicated with frailty syndrome. The combined detection of the two has certain diagnostic value for patients with CHD complicated with frailty syndrome.Keywords Coronary heart disease; Frailty syndrome; Clara cell protein; Klotho; diagnosis

  Key words: coronary heart disease; frailty syndrome; Clara cell protein; Klotho; diagnosis

  提交时间：2025-11-07

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• 序号	提交日期	编号	操作
  1	2025-09-26	10.12201/bmr.202511.00011V1	下载

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