A controlled study of pregabalin combined with escitalopram in patients with major depressive disorder

Corresponding author: Yin Junbo, qdyjb9131@163.com

DOI: 10.12201/bmr.202501.00017

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  Abstract: Abstract: To explore the clinical efficacy and safety of escitalopram combined with pregabalin in patients with major depressive disorder. Methods: Sixty patients with recurrent depression were selected and divided into an experimental group (pregabalin combined with escitalopram, n = 30) and a control group (escitalopram, n = 30). The treatment course was 6 weeks. Before treatment and at the 2nd, 4th, and 6th weeks of treatment,Hamilton Depression Scale (HAMD-17), Hamilton Anxiety Scale (HAMA), and Treatment Emergent Symptom Scale (TESS) were used to evaluate efficacy and safety. Results: Before enrollment, there was no statistically significant difference in the scores of HAMD-17 and HAMA between the two groups (t = 0.615, P > 0.05).The scores after 2, 4, and 6 weeks of treatment were all lower than those before treatment. At the end of the 2nd week after treatment, the HAMD-17 and HAMA scores of the experimental group were lower than those of the control group (P<0.05). At the end of the 4th week after treatment, the HAMD-17 and HAMA scores of the experimental group were lower than those of the control group (P<0.05). At the end of the 6th week after treatment, the HAMD-17 and HAMA scores of the experimental group were lower than those of the control group (P<0.05). There was no statistically significant difference in the total incidence of adverse reactions between the two groups (P>0.05). Conclusion: Pregabalin combined with escitalopram can relieve anxiety symptoms and have antidepressant efficacy more quickly and effectively in patients with MDD.

  Key words: Pregabalin; Escitalopram; Major Depressive Disorder; Generalised anxiety disorder

  Submit time: 6 January 2025

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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