通讯作者: 张永华, zyh16916@163.com

DOI：10.12201/bmr.202408.00051

Study on early intervention of insomnia in depression treated by TCM syndrome differentiation

• 摘要：目的：观察中医辨证治疗失眠对于抑郁症状以及血清白细胞介素16(Interleukin-16, IL-6)和肿瘤坏死因子α(Tumor Necrosis Factor-α, TNF-α)的影响，进而讨论中医辨证治疗失眠对于减少抑郁症发生发展的效果。方法：将60例失眠障碍患者分为干预组和空白组，分别予以睡眠卫生宣教以及中医辨证治疗和单独睡眠卫生宣教。比较两组患者睡眠、抑郁情绪以及血清IL-6和TNF-α的含量变化。结果：干预2月后，干预组的匹兹堡睡眠质量指数表（Pittsburgh Sleep Quality Index, PSQI）、抑郁症筛查量表（Patient Health Questiomnare-9, PHQ-9）、中医症候积分明显下降，血清中IL-6和TNF-α的含量也显著降低，差异具有统计学意义（P<0.05）。结论：中医辨证治疗能够有效改善失眠以及抑郁情绪，从而延缓抑郁症的发生发展，是早期干预抑郁症的一个有效方法。

  关键词： 抑郁症; 早期干预; 失眠; 中医辨证论治

   

  Abstract: Objective: To observe the effect of TCM syndrome differentiation treatment of insomnia on depressive symptoms and IL-6 content and TNF-α content in serum. And then to discuss the effect of TCM syndrome differentiation treatment of insomnia on reducing the occurrence and development of depression. Methods: Sixty patients with insomnia disorder were divided into intervention group and blank group, and they were treated with sleep hygiene education plus TCM syndrome differentiation treatment and sleep hygiene education alone respectively. The changes of sleep, depression, serum IL-6 content and TNF-α content were compared between the two groups. Results: After 2 weeks of intervention, the intervention groups PSQI score, PHQ-9 score, TCM symptom score, and serum IL-6 and TNF-α content were all significantly reduced, and the difference was statistically significant (P<0.05). Conclusion: TCM syndrome differentiation treatment can effectively improve insomnia and depression, thus delaying the occurrence and development of depression, and is an effective method for early intervention of depression.

  Key words: Depression; Early Intervention; Insomnia; TCM Syndrome Differentiation and Treatment

  提交时间：2024-08-26

  版权声明：作者本人独立拥有该论文的版权，预印本系统仅拥有论文的永久保存权利。任何人未经允许不得重复使用。
• html

• 图表

• 孙海舒, 高宏杰. 基于结构方程模型的中医技术干预失眠平台设计与实现孙海舒1 高宏杰*. 2021. doi: 10.12201/bmr.202103.00001

  吴亚平, 朱国辉, 赵帆, 唐宗康, 吴亚楠. 粪菌移植对于抑郁症治疗的研究进展. 2024. doi: 10.12201/bmr.202408.00043

  陈豪特, 沈建武, 包烨华, 朱栎巧, 诸靖宇. 中西医结合治疗住院老年患者失眠症. 2024. doi: 10.12201/bmr.202407.00059

  周海, 彭斐灵, 韦昌法. 中医诊断学辨证知识图谱构建研究与实践. 2020. doi: 10.12201/bmr.202004.00036

  邓丽华, 刘晓鹰, 徐克菲. 贝利尤单抗联合中药辨证方治疗狼疮性肾炎患儿1例. 2024. doi: 10.12201/bmr.202409.00041

  王学斐, 陈曼曼, 滕玉欣, 曾波涛. 青少年抑郁症自伤自杀行为与非酶类抗氧化物及甲状腺激素水平分析. 2024. doi: 10.12201/bmr.202412.00022

  郭慧芳, 沈沛成. 慢性肾脏病中医非药物疗法研究概述. 2024. doi: 10.12201/bmr.202409.00054

  周张青, 崔龚臻, 汪雪芬, 刘涧, 徐方燕, 李惠莉. 基于结构方程模型(SEM)分析艾滋病血液透析治疗患者抑郁影响因素. 2024. doi: 10.12201/bmr.202410.00037

  侯吟儿. 基于“和稳论”论治小儿不寐经验. 2024. doi: 10.12201/bmr.202407.00028

  金宇梦, 李亚平. 调神养心汤治疗心肾不交型围绝经期失眠的临床观察. 2024. doi: 10.12201/bmr.202408.00031

• 序号	提交日期	编号	操作
  1	2024-07-20	bmr.202408.00051V1	下载

• 公开评论  匿名评论  仅发给作者 提交评论