通讯作者: 阳玉萍, 978288587@qq.com

DOI：10.12201/bmr.202611.00008

• 摘要：慢性鼻窦炎伴鼻息肉是一种以持续性鼻窦黏膜炎症、鼻息肉形成为特征的上呼吸道慢性疾病，显著降低患者生活质量并增加医疗负担。其病理核心在于2型炎症（type 2 inflammation,T2）的主导作用，约96%的患者鼻息肉组织呈现T2特征。鼻腔鼻窦上皮损伤后释放上皮源性警报素，它们通过各自独特的受体信号通路激活2型固有淋巴细胞（group 2 innate lymphoid cells,ILC2）和2型辅助性T细胞（T helper 2 cell,Th2)，启动并放大2型免疫反应，最终驱动嗜酸粒细胞浸润、黏液分泌增加、组织重塑及息肉生长。上皮源性警报素在鼻息肉组织中表达显著上调，且与疾病严重程度和嗜酸性粒细胞浸润程度相关。深入理解其驱动机制，有望为鼻息肉的精准医疗提供理论基础。

  关键词： 鼻息肉; 警报素; TSLP; IL-33; IL-25

   

  Abstract: Chronic rhinosinusitis with nasal polyps (CRSwNP) is a chronic upper airway disease characterized by persistent sinonasal mucosal inflammation and nasal polyp formation, which significantly reduces patients’ quality of life and increases healthcare burden. The core of its pathology lies in the dominant role of type 2 inflammation (T2 inflammation): approximately 96% of patients’ nasal polyp tissues exhibit T2 features. After injury to the nasal and sinonasal epithelium, epithelial-derived alarmins (TSLP, IL-33, and IL-25) are released. Through their respective unique receptor-signaling pathways, they activate ILC2s and Th2 cells, initiating and amplifying type 2 immune responses, and ultimately driving eosinophil infiltration, increased mucus secretion, tissue remodeling, and polyp growth. Studies have shown that epithelial-derived alarmins are significantly upregulated in nasal polyp tissues, and their expression levels correlate with disease severity and the degree of eosinophil infiltration. Epithelial-derived alarmins play an important role in regulating inflammatory responses; however, their correlation with eosinophil-infiltrated nasal polyps remains unclear. Exploring and identifying clinical indicators associated with eosinophil-infiltrated nasal polyps may provide new ideas for the diagnosis and treatment of nasal polyps.

  Key words: chronic rhinosinusitis with nasal polyps; alarmins; TSLP; IL-33; IL-25

  提交时间：2026-11-06

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• 序号	提交日期	编号	操作
  1	2026-10-12	10.12201/bmr.202611.00008V1	下载

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