通讯作者: 邵阳市中医医院, 4003196@qq.com

DOI：10.12201/bmr.202604.00043

Treating from the Liver Perspective: Efficacy of

• 摘要：目的：探讨中药外治“乳腺宁巴布贴”从肝论治治疗肝郁痰凝型乳腺增生病的临床疗效及对血清性激素水平的影响。方法：选取2023年4月至2025年4月在邵阳市中医医院乳腺科就诊的乳腺增生病(肝郁痰凝型)患者120例,随机分为对照组与治疗组各60例。对照组给予口服枸橼酸他莫昔芬片治疗(10 mg/次,2次/日)；治疗组在此基础上外用“乳腺宁巴布贴”,贴敷患侧乳房,每日1次,每次贴敷8小时,疗程2个月。观察两组治疗前后中医证候积分(乳房胀痛、肿块、乳头溢液、胸闷胁胀、心烦口苦)、乳腺超声指标〔乳腺腺体厚度、囊肿直径、低回声区直径〕、血清性激素水平雌二醇(E?)、孕酮(P)、泌乳素(PRL)、治疗总有效率及3个月、6个月复发率情况。结果：治疗后,两组患者中医证候积分及乳腺超声各项指标均较治疗前明显降低(P＜0.05),且治疗组优于对照组(P＜0.05)。治疗后两组E?、PRL水平均下降(P＜0.05),P水平升高(P＜0.05),治疗组改善幅度更显著(P＜0.05)。治疗组临床总有效率为93.33%,对照组为78.33%(P＜0.05)；6个月复发率治疗组4.17%,低于对照组20.00%(P＜0.05)。治疗期间两组未见严重不良反应。结论：“乳腺宁巴布贴”从肝论治治疗肝郁痰凝型乳腺增生病疗效确切,可显著改善乳腺超声指标,调节雌孕激素平衡,缓解临床症状,降低复发率,安全性良好。

  关键词： 乳腺增生病; 乳腺宁巴布贴; 肝郁痰凝; 血清性激素; 中药外治

   

  Abstract: Objective: To investigate the clinical efficacy of traditional Chinese medicine external treatment Ruxianning Babu Patch from the liver perspective in treating liver qi stagnation and phlegm coagulation type breast hyperplasia and its effects on serum sex hormone levels.Methods: A total of 120 patients with breast hyperplasia (liver qi stagnation and phlegm coagulation type) who visited the breast department of a traditional Chinese medicine hospital from April 2023 to April 2025 were selected and randomly divided into control group and treatment group with 60 cases each. The control group was given oral tamoxifen citrate tablets (10 mg/time, twice daily). The treatment group received additional external application of Ruxianning Babu Patch on the affected breast, once daily for 8 hours each time, with a treatment course of 2 months. The traditional Chinese medicine syndrome scores (breast distension and pain, masses, nipple discharge, chest tightness and hypochondriac distension, irritability and bitter taste), breast ultrasound indicators breast glandular thickness, cyst diameter, hypoechoic area diameter, serum sex hormone levels estradiol (E?), progesterone (P), prolactin (PRL), total treatment effectiveness rate, and recurrence rates at 3 and 6 months were observed before and after treatment in both groups.Results: After treatment, the traditional Chinese medicine syndrome scores and breast ultrasound indicators in both groups were significantly reduced compared to before treatment (P<0.05), and the treatment group was superior to the control group (P<0.05). After treatment, E? and PRL levels decreased in both groups (P<0.05), while P levels increased (P<0.05), with more significant improvement in the treatment group (P<0.05). The total clinical effectiveness rate was 93.33% in the treatment group and 78.33% in the control group (P<0.05). The 6-month recurrence rate was 4.17% in the treatment group, lower than 20.00% in the control group (P<0.05). No serious adverse reactions were observed in either group during treatment.Conclusion: Ruxianning Babu Patch treating from the liver perspective shows definite efficacy in treating liver qi stagnation and phlegm coagulation type breast hyperplasia, can significantly improve breast ultrasound indicators, regulate estrogen-progesterone balance, alleviate clinical symptoms, reduce recurrence rate, and has good safety profile.

  Key words: breast hyperplasia; Ruxianning Babu Patch; liver qi stagnation and phlegm coagulation; serum sex hormones; traditional Chinese medicine external treatment

  提交时间：2026-04-07

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• 序号	提交日期	编号	操作
  1	2025-10-23	10.12201/bmr.202604.00043V1	下载

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