通讯作者: 邓惠容, 491917213@qq.com

DOI：10.12201/bmr.202603.00094

Evaluation of the Effect of Clinical Pharmacist Pharmaceutical Science Popularization Intervention on Secondary Prevention in Patients with Ischemic Stroke

• 摘要：目的 评估临床药师实施药学科普干预对缺血性脑卒中患者二级预防的临床价值。方法 前瞻性纳入清远市人民医院脑血管病科收治的急性脑梗死患者，依据入选与排除标准筛选后，将其随机分为对照组与干预组。对照组给予常规医护健康教育，干预组在此基础之上接受由临床药师提供的系统化药学科普干预。比较两组患者出院后1个月及6个月的用药依从性、卒中复发率、改良Rankin量表（mRS）评分及药品不良反应发生率。结果 共227例患者入组，随访期间5例失访，最终222例完成研究（对照组118例，干预组104例）。出院1个月及6个月时，干预组用药依从性评分均显著高于对照组（P＜0.05）；两组在卒中复发率、mRS评分≤2分的患者比例以及药品不良反应发生率方面，差异均无统计学意义（P＞0.05）。结论 临床药师实施的系统化药学科普干预能够显著提高缺血性脑卒中患者出院后的用药依从性，，为二级预防措施的有效实施提供了重要支撑。

  关键词： 药学科普; 缺血性脑卒中; 二级预防; 临床药师

   

  Abstract: Objective To evaluate the clinical value of pharmaceutical science popularization interventions conducted by clinical pharmacists in the secondary prevention of ischemic stroke patients. Methods Patients with acute cerebral infarction admitted to the Department of Cerebrovascular Diseases at Qingyuan Peoples Hospital were prospectively enrolled. After screening based on inclusion and exclusion criteria, they were randomly assigned to the control group and the intervention group.. The control group received routine health education from medical staff, while the intervention group received additional systematic pharmaceutical science popularization interventions provided by clinical pharmacists. Medication adherence, stroke recurrence rate, modified Rankin Scale (mRS) scores, and the incidence of adverse drug reactions were compared between the two groups at 1 month and 6 months after discharge. Results A total of 227 patients were enrolled. During follow-up, 5 patients were lost, leaving 222 patients who completed the study (control group: 118; intervention group: 104). At both 1 month and 6 months after discharge, medication adherence scores were significantly higher in the intervention group than in the control group (P<0.05). There were no statistically significant differences between the two groups in stroke recurrence rate, the proportion of patients with mRS scores≤2, or the incidence of adverse drug reactions (P>0.05). Conclusion Systematic pharmaceutical science popularization intervention conducted by clinical pharmacists significantly improved medication adherence in patients with ischemic stroke after discharge, thereby providing crucial support for the effective implementation of secondary prevention.

  Key words: Pharmaceutical science popularization; Ischemic stroke; Secondary prevention; Clinical pharmacist

  提交时间：2026-03-20

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• 序号	提交日期	编号	操作
  1	2026-02-14	10.12201/bmr.202603.00094V1	下载

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