通讯作者: 王东华, 275606469@qq.com

DOI：10.12201/bmr.202601.00042

The research for effect on visual related quality of life in patients with retinal vein occlusion and macular edema treated by Intravitreal injection

• 摘要：目的:探讨玻璃体腔注射治疗对缺血型视网膜颞上分支静脉阻塞黄斑水肿患者视觉相关生活质量及眼表的影响。方法:选取2023年12月至2024年11月在承德医学院附属医院眼科就诊的并通过散瞳眼底检查、OCT及荧光素眼底血管造影等检查符合缺血型视网膜颞上分支静脉阻塞黄斑水肿患者120例,其中男性67例,女性53例,使用随机数字表法将充分知情同意后入选的患者随机分为观察组(60例)和对照组(60例),观察组给予玻璃体腔药物注射治疗,使用药物:雷珠单抗注射液,剂量:0.5mg/次,玻璃体腔内注射；对照组给予视网膜激光光凝治疗,光斑直径 200～400μm,能量140～200mw,激光曝光时间0.2～0.3s,输出功率为2～3级光斑反应,两组治疗医师均为同一人,并分别在治疗前及治疗完成后1月观察患者视力变化、视功能相关生活质量量表评分及视觉模拟量表评分。结果:最佳矫正视力视力:治疗后观察组视力提升明显优于对照组(P＜0.05)。视功能相关生活质量量表问卷:治疗后观察组较治疗前组内12个维度均呈现出上升趋势(P＜0.05)；治疗后对照组较治疗前组内,除眼部不适一项外,其他各项维度呈现出上升趋势,且存在统计学意义(P＜0.05)；两组治疗后组间比较,观察组在除整体健康、眼部不适、驾车及精神健康四项外,其余各个维度均明显优于对照组(P＜0.05)。视觉模拟量表问卷:观察组治疗前后各项均呈下降趋势(P＜0.05),对照组除异物感和眼部不适无明显变化外,其他各项呈现上升趋势(P＜0.05)；两组治疗后组间比较,观察组各项评分均低于对照组(P＜0.05)。结论:玻璃体腔药物注射较传统视网膜激光在治疗缺血型视网膜颞上分支静脉阻塞黄斑水肿时可以有效改善患者视觉相关生活质量及眼表的状态。

  关键词： 视网膜静脉阻塞; 黄斑水肿; 玻璃体腔注射; 视网膜激光; 视功能相关生活质量量表; 视觉模拟量表

   

  Abstract: Objective:To explore the impact of intravitreal injection therapy on visual-related quality of life and ocular surface in patients with macular edema caused by ischemic superior temporal branch retinal vein occlusion.Methods:120 patients were selected who visited the ophthalmology department of the Affiliated Hospital of Chengde Medical College from December 2023 to November 2024 and met the criteria for ischemic superior temporal branch retinal vein occlusion with macular edema through dilated pupil fundus examination, OCT,and fluorescein fundus angiography.Among them,there were 67 males and 53 females.After obtaining full informed consent, the enrolled patients were randomly divided into an observation group (60 cases) and a control group (60 cases) using a random number table method.The observation group underwent intravitreal drug injection therapy,using the drug Ranibizumab Injection,with a dosage of 0.5mg per injection,administered through intravitreal injection.The control group received retinal laser photocoagulation treatment with a spot diameter of 200-400μm, energy of 140-200mw,laser exposure time of 0.2-0.3s,and output power of 2-3 level spot response. Both groups were treated by the same physician,and changes in visual acuity,scores on the visual function-related quality of life scale,and scores on the visual analog scale were observed before treatment and one month after treatment completion.Results:Best corrected visual acuity: After treatment,the improvement in visual acuity in the observation group was significantly better than that in the control group (P<0.05).Visual function-related quality of life scale questionnaire: After treatment,the observation group showed an upward trend in all 12 dimensions compared to the pre-treatment group (P<0.05);after treatment,the control group showed an upward trend in all dimensions except for ocular discomfort compared to the pre-treatment group, and the differences were statistically significant (P<0.05);in the comparison between the two groups after treatment,the observation group was significantly better than the control group in all dimensions except for overall health,ocular discomfort,driving,and mental health (P<0.05).Conclusion:Intravitreal drug injection is more effective than traditional fundus laser therapy in improving patientsvisual-related quality of life and ocular surface status when macular edema caused by ischemic temporal superior branch retinal vein occlusion.

  Key words: retinal vein occlusion; macular edema; intravitreal injection; laser for retina; visual function questionnaire; visual analog scale

  提交时间：2026-01-14

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• 序号	提交日期	编号	操作
  1	2025-12-26	10.12201/bmr.202601.00042V1	下载

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