Acute urethral obstruction caused by urinary tract infection induced by pegylated interferon alpha in the treatment of chronic hepatitis b: a case report

DOI: 10.12201/bmr.202408.00052

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  Abstract: Although adverse reactions related to interferon are common, cases of urinary tract infection leading to acute urethral obstruction are rare. This article retrospectively analyzes a case of chronic hepatitis B patients who were treated with pegylated interferon alpha antiviral therapy and developed urinary tract infection leading to acute urethral obstruction. The patient presented with high fever, urinary irritation, lower abdominal pain, and perineal distension. In severe cases, there were clinical manifestations of acute urethral obstruction. After completing urine and blood-related examinations and imaging tests, it was diagnosed as urinary tract infection and acute urethral obstruction. After stopping interferon treatment and timely anti-infection and symptomatic treatment, the patients urination function returned to normal. During the treatment with interferon, male patients, especially elderly or patients with enlarged prostate, need to be closely monitored for adverse drug reactions. Patients should be informed in advance of the possibility of urinary tract infection and even acute urethral obstruction. Early detection and timely effective treatment measures should be taken to avoid delayed treatment.

  Key words: Chronic hepatitis B; Interferon; Urinary tract infection；Urethral obstruction; 

  Submit time: 26 August 2024

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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