Biological characteristics of PE/PPE family genes of mycobacterium tuberculosis

Corresponding author: WANG Xiao-Chun▲, 3061913@qq.com

DOI: 10.12201/bmr.202511.00054

•  

  Abstract: Tuberculosis (TB)is a chronic respiratory infectious disease caused by the infection of Mycobacterium tuberculosis (M.tb), which remains one of the deadliest diseases with a significant global threat, severely endangering human life and health. Among the mycobacteria, there exists a special protein family known as the PE/PPE protein family, consisting of two subfamilies, PE and PPE, whose encoding genes occupy 10% of the entire genome. In recent years, many experimental data have fully confirmed that the PE/PPE protein family plays a key role in the pathogenesis of tuberculosis. Therefore, in order to reduce the infection rate and incidence of TB and achieve a zero mortality rate from TB, further research on PE/PPE family proteins is essential. This article will review the structure, antigenicity, physiological functions, and clinical applications of the PE/PPE family genes of Mycobacterium tuberculosis, hoping to provide useful references for the development of immune-enhancing vaccines and serological diagnosis of tuberculosis.

  Key words: Mycobacterium tuberculosis; PE/PPE gene; Functional Characteristics; Clinical Application

  Submit time: 20 November 2025

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
• html

• 图表

• He Fei. Application of preserving stomach qi in differentiating and treating non-tuberculous Mycobacterium lung disease in traditional Chinese medicine. 2024. doi: 10.12201/bmr.202407.00002

  He Fei. . 2025. doi: 10.12201/bmr.202504.00032

  Yu Xin. Application and research progress of molecular detection techniques in the diagnosis of childhood tuberculosis. 2025. doi: 10.12201/bmr.202506.00029

  GU Yanhong. Study and evaluation of diagnostic methods for HIV co-infection with tuberculosis: a network meta-analysis. 2024. doi: 10.12201/bmr.202411.00005

  wang xiangming. Application of holistic functional teaching in clinical teaching of chronic kidney disease. 2024. doi: 10.12201/bmr.202406.00016

  Bioinformatics analysis of differentially expressed genes in diabetic foot based on the GEO gene dataset. 2025. doi: 10.12201/bmr.202502.00048

  Fengjunkai, Wangyifan. Visual analysis of Chinese medicine treatment of bone tuberculosis based on bibliometrics and knowledge mapping. 2025. doi: 10.12201/bmr.202501.00039

  Yao Yiqing, WEN Tingxiao, Qiu Huan Yang. A review of the physiological characteristics and application of eye movement. 2024. doi: 10.12201/bmr.202412.00079

  cheng lingjing, li hetong, zhang shengxiao, liu hongqi, yu qi, zheng chaoyue, feng shuang, kong teng, sun xiangfei, he peifeng, LV Xiao-ping. Protein-based bioinformatics analysis of cervical cancer-related genes. 2023. doi: 10.12201/bmr.202303.00017

• ID	Submit time	Number	Download
  1	2025-10-30	10.12201/bmr.202511.00054V1	Download

• Public  Anonymous  To author only Submit Comments