Exploring Professor Xiong Yan

Corresponding author: ZHANGT Tao, hello＿zhangtao@aliyun.com

DOI: 10.12201/bmr.202509.00053

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  Abstract: Non-alcoholic fatty liver disease (NAFLD) has a complex pathogenesis. In traditional Chinese medicine (TCM), its occurrence is closely associated with dietary habits, emotional factors, and constitutional predisposition. Based on the “Xiao Fa” (dispersion method) theory, this article systematically summarizes Professor Xiong Yan’s clinical experience in treating NAFLD, highlighting innovations in pathological mechanism interpretation and stratified treatment.Professor Xiong identifies three key pathological mechanisms: dietary irregularities leading to spleen-stomach impairment, emotional disorders causing liver stagnation overacting on the spleen, and congenital deficiency resulting in phlegm and stasis binding together. These factors interact, ultimately leading to liver-spleen dysfunction and phlegm-stasis obstruction.Therapeutically, centering on “Xiao Fa,” a stratified treatment approach is adopted: promoting digestion and removing stagnation, awakening the spleen and resolving turbidity to strengthen the middle energizer; soothing the liver and relieving depression, eliminating stagnation and harmonizing collaterals to regulate qi movement; resolving phlegm and dissipating stasis, supporting healthy qi and unblocking collaterals to eliminate pathogens and consolidate constitution. Professor Xiong also developed the empirical formula “Zhi Kang Yin” to simultaneously address the liver and spleen, and treat both phlegm and stasis, reflecting the uniqueness and practicality of his clinical approach. This provides a new effective formula and clinical pathway for TCM treatment of NAFLD.

  Key words: Non-alcoholic fatty liver disease，Therapy of Dispelling，Zhi Kang Yin，Experience

  Submit time: 24 September 2025

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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