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Corresponding author: duzhicai

DOI: 10.12201/bmr.202506.00020

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  Abstract: 【Abstract】Objective To systematically evaluate the influencing factors of surgical site infection in patients after posterior lumbar interbody fusion. Methods We searched PubMed, Web of Science, Embase, Cochrane Library and other internationally renowned databases, as well as domestic authoritative databases such as CNKI, Wanfang, and VIP, from the establishment of each database to April 1, 2024. Two independent researchers conducted preliminary screening and data extraction, Newcastle-Ottawa Scale (NOS) was used to score the quality of the included studies, and RevMan 5.4 and Stata 15.1 were used to conduct in-depth meta-analysis of the extracted data. Results A total of 21 studies were included, with a total sample of 14631 cases. Conclusion Independent risk factors for surgical site infection in patients after posterior lumbar interbody fusion include age>60 years (RR=1.73, 95%CI: 1.27, 2.35). Operative time ≥ 3 hours (RR=2.37, 95%CI: 1.83, 3.08); postoperative cerebrospinal fluid leak (RR=2.62, 95%CI: 1.29, 5.33); diabetes mellitus (RR = 1.97, 95% CI: 1.68, 2.30); cigarette smoking (RR = 1.50, 95% CI: 1.16, 1.95); Drain placement was ≥ 2 days (RR = 2.02, 95% CI: 1.33, 3.06); alcohol consumption (RR = 1.51, 95% CI: 1.04, 2.19); 3 fusion segments ≥ (RR=2.65, 95%CI: 1.59, 4.43); Postoperative albumin water < 3.5 g/dl (RR=3.35, 95%CI: 1.71, 6.56); Length of stay before surgery (RR = 1.13, 95% CI: 1.05, 1.21). Male sex was an independent protective factor for surgical site infection after posterior lumbar interbody fusion (RR=0.69, 95%CI: 0.52, 0.92).【Keywords】posterior lumbar interbody fusion; Infect; influencing factors; Meta-analysis

  Key words: [keywords missed]

  Submit time: 8 June 2025

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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