Construction of supportive care protocols for patients treated with CAR-T cells for lymphoma

DOI: 10.12201/bmr.202502.00029

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  Abstract: Abstract:Objective:Based on the need for supportive care, a supportive care scheme for patients treated with lymphoma chimeric antigen receptor T(CAR-T) cells was established.Methods: A questionnaire for supportive care program was initially constructed through a literature review and semi-structured interviews, and then refined through two rounds of Delphi method. Results: The response rate for the two rounds of questionnaires was 100%. The expert coefficient of authority was 0.903, and the Kendalls coefficient of concordance was 0.253 and 0.262, respectively. The final program included five primary categories (health information support, physiological symptoms and daily living support, psychological support, care and emotional support, and safety support), 20 secondary categories, and 50 tertiary categories. Conclusion: The supportive care program developed in this study for patients receiving CAR-T cell therapy for lymphoma has certain scientific and feasibility.

  Key words: Lymphoma; Chimeric antigen receptor T-cell therapy; Supportive care; Program construction

  Submit time: 18 February 2025

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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