Progress in the application of dexmedetomidine in anesthesia through nasal administration

Corresponding author: zhanglei, 1602856157@qq.com

DOI: 10.12201/bmr.202409.00057

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  Abstract: exmedetomidine is a hepatically eliminated drug ，as an α2-adrenergic receptor agonist, demedetomidine exerts sedative, analgesic, anti-anxiety, and decrease the incidence of chill without causing respiratory depression by acting on the G-protein-coupled receptor in the brain locus locus locus and the postsynaptic membrane a2 receptor in the posterior horn of the spinal cord through traditional intravenous administration, but it also causes hemodynamic fluctuations. In the special population, this effect may be more prominent. In this review, the research progress of demedetomidine intranasal titration, a new administration method for the elderly population, was reviewed, and its influence on the elderly was explored, in order to provide a new direction, mental thinking and new method for clinical treatment of special population.

  Key words: exmedetomidine; Nasal; Pharmacology; Anesthesia

  Submit time: 25 September 2024

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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  1	2024-08-18	10.12201/bmr.202409.00057V1	Download

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