通讯作者: 周金华, jsjhzh@126.com

DOI：10.12201/bmr.202510.00028

Experience and Literature Review on Multidisciplinary Collaborative Neoadjuvant Chemotherapy in the Diagnosis and Treatment of Pregnancy-Associated Cervical Cancer

• 摘要：子宫颈癌作为妊娠合并恶性肿瘤中最常见的妇科恶性肿瘤之一,随着女性生育年龄的推后和肿瘤年轻化发病趋势,子宫颈癌发病高峰年龄段与妊娠高峰年龄段的重合率越来越高,妊娠合并子宫颈癌的发病率也呈逐渐上升趋势。因其复杂性及缺乏大样本队列研究和临床试验,治疗需同时考虑母儿的耐受情况,以及医学伦理学等多方面的问题,往往需要多学科团队综合评估病情后制定个体化治疗方案。现报告多学科团队协作诊疗妊娠合并子宫颈癌1例,在新辅助化疗(neoadjuvant chemotherapy,NACT)后,经计划行剖宫产终止妊娠的同时行子宫颈癌根治术,对该患者的治疗方案及母儿结局进行随访分析,旨在为妊娠合并子宫颈癌患者选择更合适的治疗方案、治疗时机以及终止妊娠时机,从而避免延误治疗,为临床治疗及改善新生儿预后提供临床参考。

  关键词： 多学科诊疗，新辅助化疗，妊娠，子宫颈癌; ; ; 

   

  Abstract: Cervical cancer is one of the most common gynecologic malignant tumors in pregnancy. The increasing age of women at childbirth and a rising incidence of tumors in younger individuals have led to a growing occurrence of cervical cancer during pregnancy due to a convergence in the peak ages for both conditions. The complexity of managing this dual condition, compounded by the limited availability of extensive cohort studies and clinical trials, underscores the necessity for a treatment approach that prioritizes the well-being of both the mother and the fetus, while upholding medical ethics. This typically involves the collaboration of multidisciplinary teams to conduct a thorough assessment of the patients condition and devise individualized treatment plans. This study presents a case of cervical cancer complicating pregnancy that was addressed by a multidisciplinary team. The patient underwent neoadjuvant chemotherapy (neoadjuvant chemotherapy,NACT) followed by a planned cesarean section to conclude the pregnancy, in conjunction with a radical hysterectomy. The treatment regimen and subsequent outcomes for both the mother and the fetus were meticulously monitored and assessed. The primary objective of this study was to delineate optimal treatment strategies, intervention timing, and pregnancy termination schedules for instances of cervical cancer during pregnancy. The research aims to mitigate treatment delays, provide valuable clinical perspectives, and improve neonatal prognosis through evidence-based approaches.

  Key words: multidisciplinary,neoadjuvant; chemotherapy, pregnancy, cervical; cancer, case; report

  提交时间：2025-10-17

  版权声明：作者本人独立拥有该论文的版权，预印本系统仅拥有论文的永久保存权利。任何人未经允许不得重复使用。
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• 序号	提交日期	编号	操作
  1	2025-07-18	bmr.202510.00028V1	下载

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