通讯作者: 丁荔, 2598479410@qq.com

DOI：10.12201/bmr.202509.00008

Current Research Status on Magnesium Ion Levels and Prognosis of Sepsis

• 摘要：脓毒症是由感染引发的危及生命的器官功能障碍,死亡率较高,早期识别与干预至关重要。镁离子作为人体内重要阳离子,参与多种酶促反应,却常被忽视,在重症患者中更易出现代谢异常,且与脓毒症不良预后密切相关。脓毒症本质是炎症性疾病,存在免疫平衡打破、凝血紊乱等病理生理过程。镁离子具有参与细胞代谢、调节神经传导、影响炎症免疫反应等多种生理功能。脓毒症患者中低镁血症更常见,发生率达 40%-60%,与多项不良预后指标相关。其在脓毒症中通过抑制炎症通路、调节免疫细胞功能等发挥免疫调节作用。临床研究显示,补充镁剂可改善脓毒症患者乳酸清除率、缩短住院时间、降低死亡率等。但目前镁离子评估存在局限,补镁的最佳方案也不明确,未来需进一步研究以明确其在脓毒症治疗中的价值。

  关键词： 镁离子; 脓毒症; 低镁血症; 炎症反应; 氧化应激。

   

  Abstract: Sepsis, a life-threatening organ dysfunction triggered by infection with high mortality, necessitates early identification and intervention. As a vital cation in the human body, magnesium ions participate in various enzymatic reactions yet are frequently overlooked. They are more susceptible to metabolic abnormalities in critically ill patients and closely linked to poor prognosis in sepsis.Fundamentally, sepsis is an inflammatory disorder involving pathophysiological processes such as disrupted immune homeostasis and coagulopathy. Magnesium ions possess multiple physiological functions, including involvement in cellular metabolism, regulation of nerve conduction, and modulation of inflammatory and immune responses.Hypomagnesemia is more prevalent in sepsis patients, with an incidence of 40%-60%, and correlates with multiple poor prognostic indicators. In sepsis, magnesium ions exert immunomodulatory effects through inhibition of inflammatory pathways and regulation of immune cell functions.Clinical studies indicate that magnesium supplementation can enhance lactate clearance, shorten hospital stays, and reduce mortality in sepsis patients. However, current limitations exist in magnesium ion assessment, and the optimal magnesium supplementation regimen remains undefined. Further research is required to clarify its value in sepsis treatment.

  Key words: Magnesium ions; Sepsis; Hypomagnesemia; Inflammatory response; Oxidative stress.

  提交时间：2025-09-01

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• 序号	提交日期	编号	操作
  1	2025-08-23	bmr.202509.00008V1	下载

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