通讯作者: 孙霞, 403343150@qq.com

DOI：10.12201/bmr.202610.00003

Clinical Observation on Quyu Tongluo Formula Fumigation and Washing Combined with Mecobalamin Tablets in Patients with Diabetic Peripheral Neuropathy of Blood Stasis Type

• 摘要：目的：探讨祛瘀通络方熏洗联合甲钴胺片治疗血瘀型糖尿病周围神经病变（diabetic peripheral neuropathy,DPN）的临床疗效。方法：选取丽水市中医院2023年10月-2024年5月期间确诊并接受治疗的64例血瘀型DPN患者，对所有患者的诊疗资料开展回顾性分析。本研究采用观察设计，未实施随机分组，由已发生的临床结局回溯患者既往接受的治疗暴露，按照患者是否接受祛瘀通络方熏洗干预分为对照组与治疗组，每组各32例。两组均为基础降糖治疗，对照组予口服甲钴胺片，治疗组在此基础上加用祛瘀通络方外用熏洗，疗程均为4周。比较两组中医证候积分、多伦多临床神经病变量表 (Toronto Clinical Scoring System,TCSS) 评分、中医证候疗效、神经传导速度及血清肿瘤坏死因子-α（tumor necrosis factor-α,TNF-α）、白细胞介素-6（interleukin-6，IL-6）水平。结果：治疗组整体有效率达93.7%，显著高于对照组的75.0%（P<0.05）。治疗结束后，两组患者中医证候积分、TCSS评分以及TNF-α、IL-6炎症因子水平均较治疗前降低，神经传导速度均较治疗前升高（P<0.05），且治疗组改善程度明显优于对照组（P<0.05）。结论：在常规降糖联合甲钴胺治疗基础上，加用祛瘀通络方熏洗可更为有效地改善血瘀型DPN患者临床症状，减轻炎症反应，提高神经传导速度，且安全性良好，值得临床推广。

  关键词： 糖尿病周围神经病变; 祛瘀通络方; 熏洗; 血瘀型; 神经传导速度; 炎症因子

   

  Abstract: Objective: To evaluate the clinical efficacy of fumigation and washing with Quyu Tongluo Decoction combined with methylcobalamin tablets in treating blood stasis-type diabetic peripheral neuropathy (DPN). Methods: A retrospective analysis was conducted on 64 patients diagnosed with blood stasis-type DPN and treated at Lishui Hospital of Traditional Chinese Medicine between October 2023 and May 2024. This observational study did not involve randomization; instead, it analyzed existing clinical outcomes to trace prior treatment exposures. Patients were divided into a control group and a treatment group, each comprising 32 cases, based on whether they received fumigation and washing with Quyu Tongluo Decoction. Both groups received standard glucose-lowering therapy. The control group took oral methylcobalamin tablets, while the treatment group additionally underwent external fumigation and washing with Quyu Tongluo Decoction. The treatment duration for both groups was four weeks. Outcomes assessed included TCM syndrome scores, Toronto Clinical Scoring System (TCSS) scores, therapeutic effects according to TCM syndrome, nerve conduction velocity, and serum levels of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6). Results: The overall effective rate in the treatment group was 93.7%, significantly higher than the 75.0% in the control group (P < 0.05). After treatment, both groups showed significant reductions in TCM syndrome scores, TCSS scores, and inflammatory markers TNF-α and IL-6, as well as improvements in nerve conduction velocity compared to baseline (P < 0.05). Moreover, the improvement in the treatment group was significantly greater than that in the control group (P < 0.05). Conclusion: Adding fumigation and washing with Quyu Tongluo Decoction to conventional glucose-lowering therapy and methylcobalamin treatment can more effectively alleviate clinical symptoms, reduce inflammation, improve nerve conduction velocity, and is safe, making it worthy of clinical promotion.

  Key words: ; ; ; ; ; 

  提交时间：2026-10-03

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• 序号	提交日期	编号	操作
  1	2026-06-30	10.12201/bmr.202610.00003V1	下载

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