通讯作者: 陈波, chenbomed@163.com

DOI：10.12201/bmr.202607.00041

Effects of Fine-Needle Acupuncture on Hypothalamic NPY Neurons and Gastrointestinal Hormones in Simple Obesity

• 摘要：单纯性肥胖以能量摄入与消耗失衡为主要病理基础,摄食调控异常是其发生发展的重要环节。下丘脑弓状核NPY/AgRP神经元与POMC/CART神经元共同构成摄食调节核心网络,NPY过度表达可增强饥饿信号、促进进食和脂肪蓄积。毫针针刺作为临床常用干预方式,具有操作简便、安全性较高、患者接受度较好等特点。现有研究提示,毫针针刺可能通过降低下丘脑或血清NPY水平,改善NPY/AgRP与POMC/CART神经元功能平衡；同时可影响PYY、GLP-1、CCK等胃肠激素分泌,经脑-肠轴增强饱腹信号,间接抑制NPY介导的促食效应。Ghrelin与NPY关系密切,但毫针针刺后其变化方向尚不一致,可能受胃肠动力、能量负平衡和检测时点等因素影响。本文以NPY为核心,梳理毫针针刺治疗单纯性肥胖中下丘脑摄食神经元与胃肠激素的关联机制,以期为临床应用和后续实验研究提供参考。

  关键词： 毫针针刺; 单纯性肥胖; 下丘脑; 神经肽Y; 胃肠激素; 脑-肠轴

   

  Abstract: Simple obesity is primarily characterized by an imbalance between energy intake and expenditure, with abnormalities in feeding regulation playing a crucial role in its onset and progression. NPY/AgRP neurons and POMC/CART neurons in the arcuate nucleus of the hypothalamus collectively form the core network for feeding regulation; overexpression of NPY can enhance hunger signals, promote food intake, and increase fat accumulation. Fine-needle acupuncture, a commonly used clinical intervention, is characterized by its ease of administration, high safety profile, and good patient acceptance. Existing research suggests that fine-needle acupuncture may improve the functional balance between NPY/AgRP and POMC/CART neurons by reducing hypothalamic or serum NPY levels; simultaneously influencing the secretion of gastrointestinal hormones such as PYY, GLP-1, and CCK, which enhance satiety signals via the brain-gut axis and indirectly inhibit NPY-mediated pro-feeding effects. Ghrelin is closely related to NPY, but changes in ghrelin levels following fine-needle acupuncture remain inconsistent and may be influenced by factors such as gastrointestinal motility, negative energy balance, and the timing of measurement. Focusing on NPY, this paper examines the mechanisms linking hypothalamic feeding neurons and gastrointestinal hormones in the treatment of simple obesity with filiform acupuncture, with the aim of providing guidance for clinical applications and future experimental research.

  Key words: ; ; ; ; ; 

  提交时间：2026-07-26

  版权声明：作者本人独立拥有该论文的版权，预印本系统仅拥有论文的永久保存权利。任何人未经允许不得重复使用。
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• 序号	提交日期	编号	操作
  1	2026-06-28	10.12201/bmr.202607.00041V1	下载

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