通讯作者: 卢志山, dentlzs@163.com

DOI：10.12201/bmr.202605.00092

The effects of purified saponin solution from sapindus mukorossi on the removal of root canal smear layer and dentin microhardness

• 摘要：探讨不同浓度无患子皂苷冲洗液对根管玷污层清除效果及牙本质显微硬度的影响。方法 收集90颗新鲜拔除的单根管前磨牙，使用ProTaper机用镍钛锉根管预备。根据终末冲洗方案随机分为6组。对照组：0.9%的生理盐水；A组：5mg/ml皂苷冲洗液；B组：10mg/ml皂苷冲洗液；C组：15mg/ml皂苷冲洗液；D组：20mg/ml皂苷冲洗液；E组：17%EDTA。使用扫描电镜（Scanning electron microscopy，SEM）观察根管冲洗后根管壁玷污层清除效果，维氏显微硬度仪测量冲洗前后牙本质的显微硬度。结果 （1）根上1/3和根中1/3玷污层清除效果：对照组玷污层评分高于其余组（P<0.05），E组玷污层评分低于A、B组（P<0.05）；（2）根尖1/3玷污层清除效果：对照组玷污层评分高于其余组（P<0.05），E组玷污层评分低于A组（P<0.05），高于C、D组（P<0.05），而C组和D组之间无统计学差异（P>0.05）。（3）E组显微硬度下降值大于其余组（P<0.05），其他组间比较无明显差异（P>0.05）。结论 15mg/ml无患子皂苷冲洗液在根尖1/3去除玷污层效果明显优于17%EDTA，并且对牙本质显微硬度无明显影响，有望作为潜在的根管终末冲洗剂。

  关键词： 无患子; 皂苷; 根管冲洗; 玷污层; 显微硬度

   

  Abstract: Objective To investigate the effects of different concentrations of Sapindus saponin irrigating solutions on the removal of root canal smear layer and dentin microhardness. Methods Ninety extracted single-rooted premolars were collected and instrumented using ProTaper rotary nickel-titanium files. Divided randomly into 6 groups according to different final irrigation protocols: Control group: 0.9% normal saline;Group A: 5 mg/mL saponin solution; Group B: 10 mg/mL saponin solution; Group C: 15 mg/mL saponin solution; Group D: 20 mg/mL saponin solution; Group E: 17% EDTA. Scanning electron microscopy was used to observe the removal effect of the smear layer and the microhardness of the dentin before and after irrigation was measured by Vickers microhardness tester. Results (1) Smear layer removal in the coronal and middle thirds: Control group had higher smear layer scores than the other groups (P<0.05), and Group E had lower scores than Groups A and B (P<0.05). (2) Smear layer removal in the apical third: Control group had higher smear layer scores than the other groups (P<0.05); Group E had lower scores than Group A (P<0.05) but higher scores than Groups C and D (P<0.05), while no statistically significant difference was observed between Groups C and D (P>0.05). (3) The magnitude of microhardness reduction was greater in Group E than in the other groups (P<0.05), whereas no statistically significant differences were observed among the remaining groups (P>0.05). Conclusion The 15mg/mL Sapindus saponin irrigating solution demonstrates significantly superior smear layer removal in the apical third compared with 17% EDTA, with no significant effect on dentin microhardness, suggesting its potential as a final root canal irrigant.

  Key words: sapindus mukorossi; saponin; root canal irrigation; smear layer; microhardness

  提交时间：2026-05-25

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• 序号	提交日期	编号	操作
  1	2026-05-09	10.12201/bmr.202605.00092V1	下载

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