通讯作者: 杨建宇, yang90jianyu@163.com

DOI：10.12201/bmr.202604.00011

Clinical characteristics and risk factors analysis of early-onset colorectal cancer

• 摘要：目的：探究早发型结直肠癌（EOCRC）的临床特征及相关危险因素。方法：采用回顾性单中心病例对照研究，纳入在我院接受肠镜检查并确诊的200例结直肠癌患者，根据患者年龄分为EOCRC组（76例）和晚发型结直肠癌（LOCRC）组（124例）。对比两组临床资料以明确EOCRC的临床特点，将有统计学意义的临床特征纳入多因素Logistic回归模型，分析EOCRC发生的危险因素。结果：与LOCRC组相比，EOCRC组年龄更低，分期更晚，BMI、西方饮食模式、作息不规律、首发症状便秘、神经侵犯、脉管侵犯及吸烟史、溃疡型比例更高，而糖尿病史、高血压史、胃肠道肿瘤家族史及结肠息肉比例更低（P＜0.05）；多因素Logistic回归分析显示，西方饮食模式、高BMI及吸烟史、作息不规律是EOCRC发生的高危因素（P＜0.05），而高血压病史、糖尿病病史、结肠息肉则是LOCRC发生的危险因素（P＜0.05）。结论：EOCRC具有发病年龄早、肿瘤分期偏晚、侵袭性更强的临床特征，其发生与高BMI、西方饮食模式、吸烟、作息不规律等因素密切相关。

  关键词： 早发型结直肠癌；晚发型结直肠癌；临床特点；危险因素; ; ; 

   

  Abstract: Objective: To explore the clinical characteristics and related risk factors of early-onset colorectal cancer (EOCRC). Method: A retrospective single center case-control study was conducted, including 200 colorectal cancer patients who underwent colonoscopy and were diagnosed in our hospital. The patients were divided into EOCRC group (76 cases) and late-onset colorectal cancer (LOCRC) group (124 cases) according to their age. Compare two sets of clinical data to clarify the clinical characteristics of EOCRC, incorporate statistically significant clinical features into a multivariate logistic regression model, and analyze the risk factors for EOCRC occurrence. Result: Compared with the LOCRC group, the EOCRC group had lower age and later staging, BMI、 The proportion of western diet pattern, irregular work and rest, first symptom constipation, nerve invasion, vascular invasion, smoking history and ulcer type was higher, while the proportion of diabetes history, hypertension history, family history of gastrointestinal tumor and colon polyp was lower (P<0.05); Multivariate logistic regression analysis showed that western diet pattern, high BMI, smoking history and irregular work and rest were the high risk factors for EOCRC (P<0.05), while hypertension, diabetes and colon polyps were the risk factors for LOCRC (P<0.05). Conclusion: EOCRC has clinical characteristics of early onset, late tumor staging, and stronger invasiveness. Its occurrence is closely related to factors such as high BMI, Western dietary patterns, smoking, and irregular sleep patterns.

  Key words: early-onset colorectal cancer; Late onset colorectal cancer; Clinical characteristics; risk factor

  提交时间：2026-04-02

  版权声明：作者本人独立拥有该论文的版权，预印本系统仅拥有论文的永久保存权利。任何人未经允许不得重复使用。
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• 序号	提交日期	编号	操作
  1	2026-03-06	10.12201/bmr.202604.00011V1	下载

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