通讯作者: 唐奇志, nhzyytang@126.com

DOI：10.12201/bmr.202602.00023

• 摘要：继糖尿病性骨质疏松后，甲亢性骨质疏松（Hyperthyroidism-Induced Osteoporosis：HOP）已成为代谢性骨病研究领域的又一研究热点与前沿方向，现代医学认为，HOP与甲状腺激素加速骨代谢、导致骨吸收大于骨形成等密切相关。现代中医学理论体系内尚无与此病完全对应的病名，但依其证候表现，可将其归属于“瘿气”、“骨痿”。本文基于“肝肾同源”理论，系统探讨其病因病机，认为本病始于肝气郁结，郁而化火，火盛耗血，日久灼烧肾阴，耗伤精血，终致肾精亏虚，肾主骨生髓，骨枯髓减，发为“骨痿”。反之，肾精不足亦致肝失濡养，加重肝火，形成甲亢与骨质疏松相互影响的恶性循环。治疗当以“疏肝清热、滋水涵木、填精壮骨”为根本大法，并根据疾病不同阶段分期论治。本文旨在为HOP的中医诊治提供系统的理论依据和临床思路。

  关键词： 甲亢; 骨质疏松; 肝肾同源; 病因病机; 肝肾同治

   

  Abstract: Following diabetic osteoporosis, hyperthyroidism osteoporosis (HOP) has become another research hotspot and cutting-edge direction in the field of metabolic bone diseases. Modern medicine holds that HOP is closely related to the direct acceleration of bone metabolism by thyroid hormones, resulting in greater bone resorption than bone formation. There is no exact disease name corresponding to this condition within the modern theoretical system of traditional Chinese medicine. However, based on its symptom manifestations, it can be classified under the categories of gall qi and bone atrophy. Based on the theory of liver and kidney having the same origin, this article systematically explores its etiology and pathogenesis. It holds that this disease begins with liver qi stagnation, which then transforms into fire. Excessive fire consumes blood, and over time, it burns kidney Yin and depletes essence and blood, eventually leading to kidney essence deficiency. The kidney governs the bones and generates marrow. When the bones dry up and the marrow decreases, it results in bone atrophy. Conversely, insufficiency of kidney essence also leads to deficiency of liver blood. The liver loses its nourishment, and Yin fails to control Yang, thereby aggravating the hyperactivity of liver Yang and the upward inflammation of liver fire, forming a vicious cycle where hyperthyroidism and osteoporosis interact with each other. The treatment should be based on the fundamental principles of soothing the liver and clearing heat, nourishing water and retaining wood, and replenishing essence and strengthening bones, and be carried out in stages. This article aims to provide a systematic theoretical basis and clinical thinking for the diagnosis and treatment of HOP in traditional Chinese medicine.

  Key words: ; ; ; ; 

  提交时间：2026-02-06

  版权声明：作者本人独立拥有该论文的版权，预印本系统仅拥有论文的永久保存权利。任何人未经允许不得重复使用。
• html

• 图表

• 武文青, 宋思梦, 王释亮, 伍大华, 谢乐. 周慎教授基于“阴损及阳”理论从肝肾论治迟发性运动障碍经验. 2025. doi: 10.12201/bmr.202509.00038

  黄卓宏, 彭亚军, 何泽云. “精水同治，温肾为枢”——“温肾益精利小便法”论治肾劳病理论探析. 2025. doi: 10.12201/bmr.202512.00042

  罗子琦, 谢春红, 康  佳. 从肾肝脾治疗早发性卵巢功能不全经验. 2025. doi: 10.12201/bmr.202510.00036

  李俊逸, 钟康华. 血脂与骨质疏松的因果关系:基于孟德尔随机化研究. 2025. doi: 10.12201/bmr.202505.00047

  钱徐选弘, 龚文波. 基于“土得木而达”从肝脾论治慢性下肢静脉性水肿. 2026. doi: 10.12201/bmr.202603.00014

  王耀国, 唐诗诗, 刘泓泽, 安雨婷, 周毅. 基于本地大模型的骨质疏松专病数据库构建流程优化研究. 2024. doi: 10.12201/bmr.202410.00002

  胡雨, 张东兰. 基于“百病生于气”从心、肝、脾论治焦虑性失眠. 2025. doi: 10.12201/bmr.202509.00058

  许峻川, 费琦. BFH-OST和OSTA对于绝经后妇女骨质疏松风险预测的对比性研究. 2024. doi: 10.12201/bmr.202407.00019

  吴雅文, 高静媛, 彭倩倩, 刘敬未, 严涵, 杨雨旸. 老年人群骨质疏松症的研究进展. 2025. doi: 10.12201/bmr.202502.00044

  陶香, 刘一江, 彭紫凝, 何珏瑾, 毛丹宁, 王庆鹏, 彭江云. 基于“诸寒收引,皆属于肾”从“扶阳”论治系统性硬化症. 2025. doi: 10.12201/bmr.202502.00006

• 序号	提交日期	编号	操作
  1	2025-11-09	10.12201/bmr.202602.00023V1	下载

• 公开评论  匿名评论  仅发给作者 提交评论