通讯作者: 孙莲莲, 13676765501@163.com

DOI：10.12201/bmr.202510.00057

The Effect of Warming on the Disinfectant Efficacy of Povidone-Iodine and Patient Comfort

• 摘要：目的:本研究旨在验证适度加温对聚维酮碘有效碘含量及杀菌效果和患者舒适度的影响,为临床实践提供舒适的消毒方案。方法:以室温22°C的5%聚维酮碘为对照组,将分别加温至 25°C、30°C、35°C、40°C 和 45°C的5%聚维酮碘消毒液为实验组,每个温度维持1h后用 0.1 mol/L硫代硫酸钠滴定溶液对聚维酮碘消毒剂进行滴定,测定各组的有效碘含量；同时,通过悬液定量杀菌实验,计算不同温度下聚维酮碘对金黄色葡萄球菌、大肠杆菌和白色念珠菌的杀菌对数值,以杀菌对数值 ≥ 5.00(即杀灭率 ≥ 99.999%)作为高效消毒的判定标准。基于上述实验结果,进一步选用最接近体温的35℃加温组与常温组的5%聚维酮碘,分别用于皮肤消毒,采样培养后比较两组消毒合格率、体温变化及寒战发生率。结果:加温至25°C–40°C的聚维酮碘有效碘含量均显著高于室温组(P < 0.05),且在35°C时达到峰值(5.05%),而45°C时则回落至室温水平。悬液定量杀菌实验表明,在22°C–40°C范围内,5%聚维酮碘对三种试验菌种的杀菌对数值均大于5.0,灭菌率达到100%。临床消毒效果评估中,常温组与加温组各82例患者皮肤消毒合格率均为100%。在体温变化方面,消毒后15分钟及手术结束时,加温组患者的耳温均显著高于常温组,且术中低体温发生率显著降低(P < 0.05)。此外,加温组术中寒战发生率也显著低于常温组(P < 0.05)。结论:在适当温度范围内加温可提高聚维酮碘的有效碘含量,且不影响其消毒效果。使用加温至35°C的聚维酮碘进行皮肤消毒,有助于维持患者术中体温稳定,降低低体温与寒战的发生风险,从而提升手术患者的舒适度与安全性。
  关键词:聚维酮碘；有效碘含量；金黄色葡萄球菌；大肠杆菌；白色念珠菌；消毒效力
  中图分类号:R471

  关键词： 聚维酮碘；有效碘含量；金黄色葡萄球菌；大肠杆菌；白色念珠菌；消毒效力; ; ; ; ; 

   

  Abstract: Objective:This study aimed to investigate the effects of moderate warming on the available iodine content, bactericidal efficacy of povidone-iodine, and patient comfort, to provide a more comfortable disinfection protocol for clinical practice.Methods:Using 5% povidone-iodine at room temperature (22°C) as the control group, the experimental groups consisted of 5% povidone-iodine solutions warmed to 25°C, 30°C, 35°C, 40°C, and 45°C, respectively. After maintaining each temperature for 1 hour, the available iodine content was determined by titration with a 0.1 mol/L sodium thiosulfate solution. Concurrently, a quantitative suspension bactericidal test was conducted to calculate the log?? reduction values againstStaphylococcus aureus,Escherichia coli, andCandida albicansat different temperatures. A log?? reduction value ≥ 5.00 (indicating a kill rate ≥ 99.999%) was defined as the criterion for high-level disinfection. Based on these initial results, the group warmed to 35°C (closest to body temperature) and the room temperature group were selected for further comparison regarding skin disinfection. Post-disinfection sampling and culture were performed to compare the qualification rate of disinfection, changes in body temperature, and the incidence of shivering between the two groups.Results:The available iodine content in povidone-iodine warmed to 25°C–40°C was significantly higher than that in the room temperature group (P < 0.05), peaking at 35°C (5.05%), but decreasing back to room temperature levels at 45°C. The quantitative suspension bactericidal test demonstrated that within the 22°C–40°C range, the log?? reduction values of 5% povidone-iodine against the three test microorganisms all exceeded 5.0, achieving a 100% sterilization rate. In the clinical disinfection evaluation, both the room temperature group and the warmed group (35°C), each comprising 82 patients, showed a 100% skin disinfection qualification rate. Regarding body temperature changes, the tympanic temperature of patients in the warmed group was significantly higher than that in the room temperature group at both 15 minutes after disinfection and at the end of the surgery. Furthermore, the incidence of intraoperative hypothermia was significantly lower in the warmed group (P < 0.05). Additionally, the incidence of intraoperative shivering was significantly lower in the warmed group compared to the room temperature group (P < 0.05).Conclusion:Warming within an appropriate temperature range can increase the available iodine content of povidone-iodine without compromising its disinfection efficacy. Using povidone-iodine warmed to 35°C for skin disinfection helps maintain intraoperative body temperature stability, reduces the risk of hypothermia and shivering, thereby enhancing the comfort and safety of surgical patients.

  Key words: povidone-iodine; available iodine content; Staphylococcus aureus; Colibacillus; Candida albicans; Disinfectant efficacy

  提交时间：2025-10-31

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  1	2025-10-20	10.12201/bmr.202510.00057V1	下载

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