通讯作者: 李苍宁, 1292862257@qq.com

DOI：10.12201/bmr.202502.00038

The impact of spleen-invigorating and fetus-stabilizing prescription combined with Western medicine therapy on angiopoietin-1, angiopoietin-2, and blood homocysteine levels in patients with fetal growth restriction

• 摘要：目的：评估健脾固胎方联合西医治疗对胎儿生长受限（FGR）患者的促血管生成素1（Ang-1）,促血管生成素2（Ang-2）和血同型半胱氨酸（Hcy）水平的影响，探讨其对胎儿生长及胎盘血流动力学的调节作用。方法：本研究为前瞻性随机对照临床研究，纳入66例FGR患者，随机分为联合治疗组（健脾固胎方联合西医治疗）和对照组（常规西医治疗），分别在基线、治疗4周、治疗8周及分娩时评估Ang-1、Ang-2、Hcy水平、胎儿生长指标及胎盘血流动力学参数。数据采用SPSS 26.0进行统计分析，组间比较采用独立样本t检验和卡方检验。结果：治疗8周后及分娩时，联合治疗组Ang-1水平、Ang-2显著高于对照组，Hcy水平显著低于对照组（P<0.05）；胎儿头围、腹围、股骨长度及体重估算值在联合治疗组显著优于对照组（P<0.05）；脐动脉S/D比值和MCA-PI在联合治疗组也有显著改善（P<0.05）；不良反应的发生率和严重程度在两组间无显著差异（P>0.05）。结论：健脾固胎方联合西医治疗FGR患者疗效显著，不但能降低Hcy水平，同时使改善FGR患者的胎盘血流和胎儿生长情况，值得在临床推广。

  关键词： 胎儿生长受限；健脾固胎方；促血管生成素；血同型半胱氨酸; ; ; 

   

  Abstract: Objective: To evaluate the impact of the spleen-invigorating and fetus-stabilizing prescription combined with Western medicine therapy on the levels of angiopoietin-1 (Ang-1), angiopoietin-2 (Ang-2), and blood homocysteine (Hcy) in patients with fetal growth restriction (FGR), and to explore its regulatory effects on fetal growth and placental hemodynamics.Methods: This study is a prospective randomized controlled clinical trial involving 66 patients with fetal growth restriction (FGR). The patients were randomly divided into a combined treatment group (treated with Jianpi Gutai Prescription in combination with conventional Western medicine) and a control group (treated with conventional Western medicine alone). Levels of Angiopoietin-1 (Ang-1), Angiopoietin-2 (Ang-2), and Homocysteine (Hcy), fetal growth indicators, and placental hemodynamic parameters were assessed at baseline, 4 weeks of treatment, 8 weeks of treatment, and at delivery. Data were statistically analyzed using SPSS 26.0, with comparisons between groups conducted using independent-sample t-tests and chi-square tests. Results: After 8 weeks of treatment and at delivery, the levels of Ang-1 and Ang-2 in the combined treatment group were significantly higher than those in the control group, while the level of Hcy was significantly lower than that in the control group (P<0.05). The fetal head circumference, abdominal circumference, femur length, and estimated fetal weight were significantly better in the combined treatment group compared to the control group (P<0.05). There were also significant improvements in the umbilical artery S/D ratio and MCA-PI in the combined treatment group (P<0.05). There were no significant differences in the incidence and severity of adverse reactions between the two groups (P>0.05).Conclusion: The combined treatment of Jianpi Gutai Prescription (a traditional Chinese medicine prescription for strengthening spleen and securing fetus) and Western medicine for patients with fetal growth restriction (FGR) demonstrates significant efficacy. It not only reduces homocysteine (Hcy) levels but also improves placental blood flow and fetal growth in FGR patients, thus warranting clinical promotion.

  Key words: Fetal Growth Restriction; Jianpi Gutai Prescription; Angiopoietin; Blood Homocysteine

  提交时间：2025-02-20

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• 序号	提交日期	编号	操作
  1	2025-01-07	10.12201/bmr.202502.00038V1	下载

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